+1 Recommend
0 collections
      • Record: found
      • Abstract: found
      • Article: not found

      Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting.


      Blood Glucose, Vascular Patency, adverse effects, Stents, Regression Analysis, Predictive Value of Tests, blood, Nitric Oxide, Middle Aged, Leptin, Insulin Resistance, Insulin, Humans, Glucose Tolerance Test, Follow-Up Studies, physiopathology, Endothelium, Vascular, diagnosis, Diabetes Mellitus, Type 2, surgery, radiography, Coronary Restenosis, Coronary Disease, Coronary Angiography, Blood Vessel Prosthesis Implantation, Area Under Curve

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Previously undiagnosed diabetes, impaired glucose tolerance, and insulin resistance are common in patients with acute myocardial infarction and coronary heart disease (CHD) and might be involved in early restenosis after stent implantation. To evaluate whether markers of insulin resistance syndrome, including leptin, and endothelial dysfunction are related to increased rate of early restenosis, we studied nondiabetic patients with CHD after successful coronary stenting. Both patients with CHD undergoing coronary stenting (120 patients) and control subjects (58 patients) were submitted to an oral glucose tolerance test (OGTT). Fasting leptin levels and fasting and postglucose load insulin sensitivity were assessed. Endothelial function was measured by nitrite and nitrate release (NOx) during OGTT. More than 50% of patients treated with stent implantation presented impaired glucose tolerance or type 2 diabetes, which was previously undiagnosed. These patients also had higher glucose, insulin, and leptin levels than control subjects. Among the stented patients, insulin and leptin levels were higher in patients with restenosis than in patients without restenosis. A significant increase in NOx levels was found during OGTT both in patients without restenosis and in control subjects. On the contrary, NOx profiles were blunted in patients with restenosis. At multiple regression analysis, only DeltaAUC-NOx areas and insulin sensitivity index showed an independent correlation with the minimal lumen diameter at follow-up. We demonstrated that insulin resistance and endothelial dysfunction are independent predictors of early restenosis after coronary stenting.

          Related collections

          Author and article information



          Comment on this article