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      Potential role of granulocyte-monocyte colony-stimulating factor in the progression of intracranial aneurysms.

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          Abstract

          Macrophages play a central role in the inflammatory response leading to aneurysm formation, progression, and rupture. The purpose of this study was to determine whether granulocyte-monocyte colony-stimulating factor (GM-CSF) plays a role in the progression of human intracranial aneurysms. Specifically, we investigated whether there was a correlation between the aneurysm size and the concentration of GM-CSF in the lumen of intracranial aneurysms. The concentrations of GM-CSF in blood samples drawn from the lumen of 15 human unruptured saccular intracranial aneurysms of 14 consecutive patients were compared. The aneurysm size was 10.3±9 mm on average. The mean plasma concentration of GM-CSF was 27.9±3.1 pg/mL in the lumen of intracranial aneurysms. The mean plasma concentration of GM-CSF was significantly higher in aneurysms larger than 7 mm (30.1±2.8 pg/mL) compared with aneurysms smaller than 7 mm (26.4±2.4 pg/mL; p=0.02). There was a significant positive correlation between the aneurysm size and the plasma concentration of GM-CSF (Spearman's rho=0.55; p=0.04). There is a significant positive correlation between the aneurysm size and the plasma concentration of GM-CSF in aneurysm lumens. This suggests that GM-CSF, through its stimulatory function on macrophages, may promote aneurysm progression and may be a possible therapeutic target.

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          Author and article information

          Journal
          DNA Cell Biol.
          DNA and cell biology
          Mary Ann Liebert Inc
          1557-7430
          1044-5498
          Jan 2015
          : 34
          : 1
          Affiliations
          [1 ] 1 Department of Neurosurgery, Jefferson Hospital for Neuroscience, Thomas Jefferson University , Philadelphia, Pennsylvania.
          Article
          10.1089/dna.2014.2618
          4281873
          25389911
          db8395b9-b7ac-4195-b234-e96055c21d07
          History

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