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      Ipsapirone, a 5-HT1A agonist, suppresses REM sleep equally in unmedicated depressed patients and normal controls.

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          Abstract

          To determine whether ipsapirone, a 5-HT1A agonist, differentially suppresses REM sleep in depressed patients compared with normal controls, we administered placebo, ipsapirone 10 mg, or ipsapirone 20 mg in a double-blind, random order before bedtime in 18 unmedicated patients with depression and 16 age-matched, gender-matched normal controls. Compared to placebo, ipsapirone affected REM sleep measures equally in depressed patients and controls as follows: (1) increased REM latency; (2) reduced total REM percent, REM time, and REM density; and (3) delayed the onset of REM sleep. In addition, ipsapirone had similar effects in patients and controls in other sleep measures: (1) reduced total sleep time; (2) delayed sleep onset time; and (3) increased sleep latency, stage 1%, stage 2%, the amount of stage 3 & 4 sleep in the first non-REM period, and wake time after sleep onset. The study does not support the hypothesis that downregulated 5-HT1A receptors mediate the pathophysiology or sleep disturbances of depression, although further studies are needed as these patients did not differ from controls in baseline sleep measures.

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          Author and article information

          Journal
          Neuropsychopharmacology
          Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
          Elsevier BV
          0893-133X
          0893-133X
          Aug 1996
          : 15
          : 2
          Affiliations
          [1 ] Department of Psychiatry, University of California, San Diego 92093-0603, USA.
          Article
          0893-133X(95)00159-B
          10.1016/0893-133X(95)00159-B
          8840346
          db859bcb-bcc4-4ca9-ac5f-6adb5effd598
          History

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