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      Cutaneous Carcinosarcoma with Metastasis to the Parotid Gland

      case-report

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          Abstract

          Cutaneous carcinosarcoma is a rare malignancy that exhibits both mesenchymal and epithelial components. It is similar to nonmelanoma skin cancers in terms of risk and prognostic factors. However, these malignancies are known to have a propensity for local recurrence and metastasis, even with adequate resection margins. Here we report a case of metastatic cutaneous carcinosarcoma to the parotid gland and review the relevant literature.

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          Malignant biphasic uterine tumours: carcinosarcomas or metaplastic carcinomas?

          W. McCluggage (2002)
          Uterine carcinosarcomas (malignant mixed Mullerian tumours) are highly aggressive and have traditionally been regarded as a subtype of uterine sarcoma. However, in recent years convincing evidence has suggested that most, but not all, are monoclonal in origin rather than true collision tumours. Data confirm that the carcinomatous element is the "driving force" and that the sarcomatous component is derived from the carcinoma or from a stem cell that undergoes divergent differentiation. Thus, uterine carcinosarcomas are best regarded as metaplastic carcinomas, although the designation carcinosarcoma is likely to remain. Adjuvant treatment for uterine carcinosarcoma should probably be similar to that directed against aggressive high grade endometrial carcinomas rather than being sarcoma based. Importantly, a small proportion of uterine carcinosarcomas are true collision tumours and should be recognised as such because, in some instances, the prognosis may be better than for a similar stage carcinosarcoma.
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            Cutaneous carcinosarcoma: adnexal vs. epidermal types define high- and low-risk tumors. Results of a meta-analysis.

            Tien Tran, Sigfrid A. Muller, Prakash Chaudahri … (2005)
            We report four cases of cutaneous carcinosarcoma (CS) and perform a meta-analysis of the cutaneous CS literature.
            Article 0 comments Cited 17 times – based on 0 reviews     Review now
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              Biphasic and monophasic sarcomatoid carcinomas of the lung. A reappraisal of 'carcinosarcomas' and 'spindle-cell carcinomas'.

              Gregory Swanson, Jeremy D Glasner, M. J. Wick … (1994)
              To address the premise that pulmonary "carcinosarcomas" and spindle-cell carcinomas are part of a single clinicopathologic continuum, the authors studied 21 examples of such lesions as defined by World Health Organization criteria. Two biphasic tumors demonstrated an admixture of overt carcinoma with other foci showing partial rhabdomyogenic differentiation; 15 others were histologically similar but lacked "heterologous" sarcoma-like elements; and four lesions were monophasic spindle-cell sarcomatoid carcinomas. One of the latter also contained rhabdomyosarcoma-like areas by light microscopy. Sarcomatoid components were reactive for keratin and/or epithelial membrane antigen (EMA) in 18/21 cases. In addition, desmin and muscle-specific actin were co-detected in the same spindle cells that were keratin-positive in 4 tumors, 3 of which were those with partially myogenic histologic features. Vimentin was present in keratin- or EMA-reactive sarcomatoid cells in 12 neoplasms, and all cases were labeled with an antibody to collagen type IV. Survival was poor in this group of patients; only 1 was alive at last contact. These data support the contention that "carcinosarcoma" of the lung is part of a spectrum with "spindle-cell carcinoma." It is proposed that the terms "biphasic sarcomatoid carcinoma" and "monophasic sarcomatoid carcinoma" are more apt descriptors for such tumors.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Case Rep Otolaryngol
                Journal ID (iso-abbrev): Case Rep Otolaryngol
                Journal ID (publisher-id): CRIOT
                Title: Case Reports in Otolaryngology
                Publisher: Hindawi Publishing Corporation
                ISSN (Print): 2090-6765
                ISSN (Electronic): 2090-6773
                Publication date (Print): 2014
                Publication date (Electronic): 25 September 2014
                Volume: 2014
                Electronic Location Identifier: 173235
                Affiliations
                1Department of Surgery, St Vincent's Hospital, 390 Victoria Street, Darlinghurst, NSW 2010, Australia
                2Department of Anatomical Pathology, Westmead Hospital, Cnr Hawkesbury Road & Darcy Road, Westmead, NSW 2145, Australia
                3Department of Otolaryngology, Head and Neck Surgery, Nepean Hospital, Derby Street, Penrith, NSW 2750, Australia
                4Department of Surgery, The Whiteley-Martin Research Centre, Nepean Hospital, Derby Street, Penrith, NSW 2750, Australia
                Author notes

                Academic Editor: Juan I. De Diego

                Author information
                http://orcid.org/0000-0002-6877-5414
                Article
                DOI: 10.1155/2014/173235
                PMC ID: 4190691
                PubMed ID: 25328737
                SO-VID: db92d287-8146-435e-84f5-c301066854ce
                Copyright © Copyright © 2014 Tze Ling Loh et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 21 July 2014
                Date accepted : 17 September 2014
                Categories
                Subject: Case Report

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