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Genotype Analyses in the Japanese and Belarusian Populations Reveal Independent Effects of rs965513 and rs1867277 but Do Not Support the Role of FOXE1 Polyalanine Tract Length in Conferring Risk for Papillary Thyroid Carcinoma.

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      Abstract

      Several functional single-nucleotide polymorphisms (SNPs) at the FOXE1 locus on chromosome 9q22.33 have been associated with the risk for papillary thyroid carcinoma (PTC). This study set out to elucidate whether their effects are independent, using genotyping results in populations of Asian and European descent.

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      Affiliations
      [1 ] 1 Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University , Nagasaki, Japan .
      [2 ] 2 Center for the Promotion of Interdisciplinary Education and Research, Kyoto University , Kyoto, Japan .
      [3 ] 3 Department of Human Genetics, Atomic Bomb Disease Institute, Nagasaki University , Nagasaki, Japan .
      [4 ] 4 Nagasaki University Research Center for Genomic Instability and Carcinogenesis , Nagasaki, Japan .
      [5 ] 5 Center for Genomic Medicine, Kyoto University Graduate School of Medicine , Kyoto, Japan .
      [6 ] 6 Department of Endocrinology, Belarusian Academy for Postgraduate Education , Minsk, Belarus .
      [7 ] 7 Department of Oncology, Belarusian Academy for Postgraduate Education , Minsk, Belarus .
      [8 ] 8 Kuma Hospital , Kobe, Japan .
      [9 ] 9 Ecological Genetics Laboratory, Vavilov Institute of General Genetics, Russian Academy of Sciences , Moscow, Russia .
      [10 ] 10 Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University , Nagasaki, Japan .
      Journal
      Thyroid
      Thyroid : official journal of the American Thyroid Association
      Mary Ann Liebert Inc
      1557-9077
      1050-7256
      February 2017
      : 27
      : 2
      27824288
      10.1089/thy.2015.0541

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