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      Genotype Analyses in the Japanese and Belarusian Populations Reveal Independent Effects of rs965513 and rs1867277 but Do Not Support the Role of FOXE1 Polyalanine Tract Length in Conferring Risk for Papillary Thyroid Carcinoma.

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          Abstract

          Several functional single-nucleotide polymorphisms (SNPs) at the FOXE1 locus on chromosome 9q22.33 have been associated with the risk for papillary thyroid carcinoma (PTC). This study set out to elucidate whether their effects are independent, using genotyping results in populations of Asian and European descent.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Thyroid
          Title: Thyroid : official journal of the American Thyroid Association
          Publisher: Mary Ann Liebert Inc
          ISSN (Electronic): 1557-9077
          ISSN (Print): 1050-7256
          Publication date (Electronic): February 2017
          Volume: 27
          Issue: 2
          Affiliations
          [1 ] 1 Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University , Nagasaki, Japan .
          [2 ] 2 Center for the Promotion of Interdisciplinary Education and Research, Kyoto University , Kyoto, Japan .
          [3 ] 3 Department of Human Genetics, Atomic Bomb Disease Institute, Nagasaki University , Nagasaki, Japan .
          [4 ] 4 Nagasaki University Research Center for Genomic Instability and Carcinogenesis , Nagasaki, Japan .
          [5 ] 5 Center for Genomic Medicine, Kyoto University Graduate School of Medicine , Kyoto, Japan .
          [6 ] 6 Department of Endocrinology, Belarusian Academy for Postgraduate Education , Minsk, Belarus .
          [7 ] 7 Department of Oncology, Belarusian Academy for Postgraduate Education , Minsk, Belarus .
          [8 ] 8 Kuma Hospital , Kobe, Japan .
          [9 ] 9 Ecological Genetics Laboratory, Vavilov Institute of General Genetics, Russian Academy of Sciences , Moscow, Russia .
          [10 ] 10 Department of Radiation Molecular Epidemiology, Atomic Bomb Disease Institute, Nagasaki University , Nagasaki, Japan .
          Article
          DOI: 10.1089/thy.2015.0541
          PubMed ID: 27824288
          SO-VID: db941a6f-9be1-49d0-ab10-539073a83b73
          History

          Keywords: papillary thyroid carcinoma,functional analysis of transactivation potential,case-control association study,genotype,FOXE1 polymorphism
          Data availability:
          Keywords: papillary thyroid carcinoma, functional analysis of transactivation potential, case-control association study, genotype, FOXE1 polymorphism

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