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      The Clinical Relevance of Noncriteria Antiphospholipid Antibodies.

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          Abstract

          While lupus anticoagulant (LA), anticardiolipin antibodies (aCL), anti-β2 glycoprotein I (anti-β2GPI) antibodies represent the best available and the most widely used tests in the investigation for antiphospholipid syndrome (APS), evidence gathered in recent years indicates that other antiphospholipid antibodies (aPL) specificities may also play a role in the syndrome. Several autoantibodies have been shown to be complexed with phospholipids other than cardiolipin, or to some domains of β2GPI, or else directed to other proteins of the coagulation cascade, and these have also been proposed to be of relevance to APS, and their diagnostic value and clinical utility are the focus of current research.

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          Author and article information

          Journal
          Semin. Thromb. Hemost.
          Seminars in thrombosis and hemostasis
          Thieme Publishing Group
          1098-9064
          0094-6176
          May 03 2017
          Affiliations
          [1 ] Academic Department of Vascular Surgery, Cardiovascular Division, King's College London, United Kingdom.
          [2 ] Louise Coote Lupus Unit, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
          Article
          10.1055/s-0037-1601328
          28470650

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