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      Islet Autoantibodies.

      1 , 2 , 3 , 4

      Current diabetes reports

      Springer Nature America, Inc

      Autoantibodies, GAD65, IA-2, Insulin, T1D, ZnT8

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          Abstract

          Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells. Islet antibodies, measured by sensitive and specific liquid phase assays, are the key parameters of the autoimmune response monitored for diagnostics or prognostics in patients with T1D or for disease prediction in at-risk individuals before T1D onset. Islet autoantibodies have been the main tool used to explore the natural history of T1D; this review summarizes the current knowledge about the autoantigens and the phenotype of islets autoantibodies acquired in large prospective studies from birth in children at risk of developing T1D.

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          Author and article information

          Journal
          Curr. Diab. Rep.
          Current diabetes reports
          Springer Nature America, Inc
          1539-0829
          1534-4827
          Jun 2016
          : 16
          : 6
          Affiliations
          [1 ] Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, via Olgettina 60, 20132, Milano, Italy. lampasona.vito@hsr.it.
          [2 ] Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, via Olgettina 60, 20132, Milano, Italy. lampasona.vito@hsr.it.
          [3 ] Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, via Olgettina 60, 20132, Milano, Italy.
          [4 ] Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, via Olgettina 60, 20132, Milano, Italy.
          Article
          10.1007/s11892-016-0738-2
          10.1007/s11892-016-0738-2
          27112957

          ZnT8, T1D, Insulin, IA-2, GAD65, Autoantibodies

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