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      Effects of bushen qianggu method for primary osteoporosis : A protocol for systematic review and meta-analysis

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          Abstract

          Background:

          Primary osteoporosis (POP) is one of the most common orthopedic diseases with a high risk of fracture. Effective treatment of POP is of great significance to reduce the rate of disability and improve the quality of life. Bushen qianggu (BSQG) is a classical method of TCM in treating POP. However, there is no systematic review related to BSQG for POP. The purpose of this study is to provide a comprehensive and reliable evaluation of the clinical evidence of BSQG in the treatment of POP.

          Methods and analysis:

          Relevant randomized controlled trial literature evaluating the effect of BSQG on patients with POP will be obtained by searching the PubMed, Embase, MEDLINE, Cochrane Library Central Register of Controlled Trials, China national knowledge infrastructure database, Wan fang database, Chongqing VIP information, and SinoMed from their inception to May 2020. Two researchers will select and evaluate qualified studies independently. The bone mineral density value and the incidence of fractures will be accepted as the primary outcomes. The meta-analyses will be performed by using the RevMan 5.3.

          Results:

          This study will provide a comprehensive evaluation of the efficacy and safety of BSQG method for patients with POP.

          Conclusion:

          The conclusion of our systematic review will provide evidence to judge whether BSQG is an effective intervention for patients with POP.

          Trial registration number: 10.17605/OSF.IO/ZMX3W.

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          Most cited references11

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          Osteoporosis

          Osteoporosis is a common systemic skeletal disorder resulting in bone fragility and increased fracture risk. However, management of osteoporosis and fracture prevention strategies are often not addressed by primary care clinicians, even in older patients with recent fractures. Evidence-based screening strategies will improve identification of patients who are most likely to benefit from drug treatment to prevent fracture. In addition, careful consideration of when pharmacotherapy should be started and choice of medication and duration of treatment will maximize the benefits of fracture prevention while minimizing potential harms of long-term drug exposure.
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            Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update from the American College of Physicians.

            This guideline updates the 2008 American College of Physicians (ACP) recommendations on treatment of low bone density and osteoporosis to prevent fractures in men and women. This guideline is endorsed by the American Academy of Family Physicians.
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              Screening for Osteoporosis to Prevent Fractures

              By 2020, approximately 12.3 million individuals in the United States older than 50 years are expected to have osteoporosis. Osteoporotic fractures, particularly hip fractures, are associated with limitations in ambulation, chronic pain and disability, loss of independence, and decreased quality of life, and 21% to 30% of patients who experience a hip fracture die within 1 year. The prevalence of primary osteoporosis (ie, osteoporosis without underlying disease) increases with age and differs by race/ethnicity. With the aging of the US population, the potential preventable burden is likely to increase in future years.
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                Author and article information

                Journal
                Medicine (Baltimore)
                Medicine (Baltimore)
                MEDI
                Medicine
                Wolters Kluwer Health
                0025-7974
                1536-5964
                12 June 2020
                12 June 2020
                : 99
                : 24
                : e20697
                Affiliations
                [a ] The Fifth Clinical Medical School, Guangzhou University of Chinese Medicine.
                [b ] Guangdong Second Traditional Chinese Medicine Hospital
                [c ] Guangdong Provincial Key Laboratory of Research and Development in Traditional Chinese Medicine, Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine, Guangzhou, Guangdong, China.
                Author notes
                []Correspondence: Professor Xuemeng Xu, Orthopedics Department, Guangdong Second Traditional Chinese Medicine Hospital, 60 Hengfu Road, Guangzhou, Guangdong 510095, China (e-mail: xuxuemeng@ 123456163.com)
                Article
                MD-D-20-04008 20697
                10.1097/MD.0000000000020697
                7302671
                32541521
                dbb7d3ab-3522-450a-9beb-5e7bc681c5be
                Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.

                This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

                History
                : 07 May 2020
                : 15 May 2020
                Categories
                3800
                Research Article
                Study Protocol Systematic Review
                Custom metadata
                TRUE

                bushen qianggu,meta-analysis,primary osteoporosis,protocol,systematic review

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