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      Dendritic cell regulation of TH1-TH2 development.

      1 ,
      Nature immunology
      Springer Science and Business Media LLC

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          Abstract

          Understanding the control exerted by cytokines on T helper cell subsets 1 and 2 (TH1-TH2) development has progressed to a fairly satisfying knowledge of intracellular signals and transcription factors. Less is understood about the molecular basis of TH1-TH2 development exerted by other parameters, such as how the antigen presenting cell can influence this process. Recent work suggests that dendritic cell subsets contribute significant polarizing influences on T helper differentiation, but how this comes about is less clear. In some cases known pathways may be used, as in the dendritic cell subset 1 exerting TH1 polarization by interleukin 12 (IL-12) production and STAT4 activation. In others, the effects are still in need of explanation.

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          Author and article information

          Journal
          Nat Immunol
          Nature immunology
          Springer Science and Business Media LLC
          1529-2908
          1529-2908
          Sep 2000
          : 1
          : 3
          Affiliations
          [1 ] Département de Biologie Moleculaire, Université Libre de Bruxelles, Rue des Prof. Jeener et Brochet 12, 6041 Gosselies, Belgium.
          Article
          10.1038/79734
          10973276
          dbbe5c26-b86b-4998-b761-2acbcb2bfbed
          History

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