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      Hemodynamic Effects and Variations in Plasma Renin Activity after Single Oral Administration of Oxprenolol

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          Abstract

          In 5 healthy young males who received 40 mg oxprenolol given orally in a single dose, the hemodynamic effects, plasma renin activity and blood level of oxprenolol were investigated. One hour after administration of the drug, cardiac output and heart rate decreased by 10-20 %, remained subnormal for 4 h, but returned to control levels after 6 h. Decreases in the cardiac index were directly related to decreases in the heart rate with the stroke volume only minimally affected. Mean blood pressure remained unchanged. The plasma renin activity was significantly decreased from a mean of 0.77 ng/ml/h before the administration to 0.38 ng/ml/h after 1 h and returned to the control values after 4-6 h, suggesting the β-adrenergic system to be one of the maintenance mechanisms of renin secretion. The peak concentration of oxprenolol was observed after 1 h and it decreased rapidly after 2 h. The high blood levels coincided with the hemodynamic changes and renin suppression, but these effects could still be observed, when blood oxprenolol levels had returned to rather low levels.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1974
          1974
          29 October 2008
          : 59
          : 1
          : 41-48
          Affiliations
          Tokyo Metropolitan Geriatric Hospital and The Third Department of Internal Medicine, School of Medicine, University of Tokyo, Tokyo
          Article
          169662 Cardiology 1974;59:41–48
          10.1159/000169662
          4419013
          © 1974 S. Karger AG, Basel

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          Pages: 8
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