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      BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.

      Molecular Psychiatry
      Bipolar Disorder, epidemiology, genetics, metabolism, Brain-Derived Neurotrophic Factor, Comorbidity, Humans, Methionine, Stress Disorders, Post-Traumatic, Valine

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          Abstract

          Bipolar disorder (BD) and post-traumatic stress disorder (PTSD) frequently co-occur among psychiatric patients, leading to increased morbidity and mortality. Brain-derived neurotrophic factor (BDNF) function is associated with core characteristics of both BD and PTSD. We propose a neurobiological model that underscores the role of reduced BDNF function resulting from several contributing sources, including the met variant of the BDNF val66met (rs6265) single-nucleotide polymorphism, trauma-induced epigenetic regulation and current stress, as a contributor to the onset of both illnesses within the same person. Further studies are needed to evaluate the genetic association between the val66met allele and the BD-PTSD population, along with central/peripheral BDNF levels and epigenetic patterns of BDNF gene regulation within these patients.

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          Author and article information

          Journal
          21931317
          3690922
          10.1038/mp.2011.121

          Chemistry
          Bipolar Disorder,epidemiology,genetics,metabolism,Brain-Derived Neurotrophic Factor,Comorbidity,Humans,Methionine,Stress Disorders, Post-Traumatic,Valine

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