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      Pancreatic fat deposition is increased and related to beta-cell function in women with familial partial lipodystrophy

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          Abstract

          Background

          To study pancreatic fat deposition and beta-cell function in familial partial lipodystrophy (FPLD) patients.

          Methods

          In a cross-sectional study, eleven patients with FPLD, and eight healthy volunteers were matched for age and body mass index and studied at a referral center. Body composition was assessed using dual-energy X-ray absorptiometry and the Dixon method of magnetic resonance imaging was used to quantify pancreatic and liver fat. Fasting plasma glucose, insulin, leptin, lipids and homeostasis model assessment of insulin resistance values were measured, and an oral glucose tolerance test was performed. The insulinogenic index, Matsuda insulin sensitivity index and beta-cell disposition index were calculated.

          Results

          The FPLD group presented a higher waist-to-hip ratio and fat mass ratio and lower total, truncal and lower-limb fat masses. Pancreatic and liver fat contents (log transformed) were significantly higher in the FPLD group (5.26 ± 1.5 vs. 4.08 ± 0.64, p = 0.034 and 0.77 ± 0.50 vs. 0.41 ± 0.18, p = 0.056, respectively). Pancreatic fat was inversely related to the DI (r = − 0.53, p = 0.027) and HDL-cholesterol (r = − 0.63, p = 0.003) and directly related to WHR (r = 0.60; p = 0.009), HbA1c (r = 0.58; p = 0.01) and serum triglyceride (r = 0.48, p = 0.034). Higher triglyceride and lower HDL-cholesterol levels were observed in the FPLD group.

          Conclusions

          This study demonstrated for the first time that pancreatic fat deposition is increased in FPLD. Moreover, an inverse relationship was demonstrated between pancreatic fat and beta-cell function. The findings of this study may be consistent with the expandability hypothesis and the twin cycle hypothesis.

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          Most cited references 29

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          Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp

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            Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population.

            Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the criteria used to diagnose the disorder remain poorly defined. Localized proton magnetic resonance spectroscopy (MRS) accurately measures hepatic triglyceride content (HTGC) but has been used only in small research studies. Here, MRS was used to analyze the distribution of HTGC in 2,349 participants from the Dallas Heart Study (DHS). The reproducibility of the procedure was validated by showing that duplicate HTGC measurements were high correlated (r = 0.99, P < 0.001) and that the coefficient of variation between measurements was low (8.5%). Intake of a high-fat meal did not significantly affect the measurements, and values were similar when measurements were made from the right and left hepatic lobes. To determine the "upper limit of normal" for HTGC, the distribution of HTGC was examined in the 345 subjects from the DHS who had no identifiable risk factors for hepatic steatosis (nonobese, nondiabetic subjects with minimal alcohol consumption, normal liver function tests, and no known liver disease). The 95th percentile of HTGC in these subjects was 5.56%, which corresponds to a hepatic triglyceride level of 55.6 mg/g. With this value as a cutoff, the prevalence of hepatic steatosis in Dallas County was estimated to be 33.6%. Thus MRS provides a sensitive, quantitative, noninvasive method to measure HTGC and, when applied to a large urban US population, revealed a strikingly high prevalence of hepatic steatosis.
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              Simple proton spectroscopic imaging.

               Marcus Dixon (1984)
              Simple modification of a spin echo imaging pulse sequence generates useful spectroscopic information at 0.35 T. New images are produced that show water only, fat only, and the difference between water and fat intensity. Imaging speed, spatial resolution, and signal-to-noise ratio are comparable with ordinary imaging. The method provides new parameters for tissue characterization and improved contrast between some organs.
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                Author and article information

                Contributors
                +55 21 22662553 , agodoymatos@gmail.com
                dracynthiavalerio@gmail.com
                rom_br@yahoo.com
                dmomesso@terra.com.br
                lkayat@gmail.com
                Journal
                Diabetol Metab Syndr
                Diabetol Metab Syndr
                Diabetology & Metabolic Syndrome
                BioMed Central (London )
                1758-5996
                26 September 2018
                26 September 2018
                2018
                : 10
                Affiliations
                [1 ]GRID grid.457090.f, Serviço de Metabologia, , Instituto Estadual de Diabetes e Endocrinologia (IEDE), ; Rua Visconde Silva, 52/1135 Botafogo, Rio de Janeiro, 22271-090 Brazil
                [2 ]ISNI 0000 0001 2184 6919, GRID grid.411173.1, Departamento de Radiologia, , Universidade Federal Fluminense-Section Head, Abdominal and Pelvic Imaging-CDPI Clinics, DASA Company, ; Rio de Janeiro, Brazil
                Article
                375
                10.1186/s13098-018-0375-9
                6158829
                © The Author(s) 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                Categories
                Research
                Custom metadata
                © The Author(s) 2018

                Nutrition & Dietetics

                lipodystrophy, pancreas, ectopic fat, beta cell function

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