25
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Uso de quetiapina em transtorno de humor bipolar de início precoce Translated title: Use of quetiapine for early-onset bipolar disorder

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          O transtorno do humor bipolar de início na infância e adolescência tornou-se um grande desafio aos profissionais que atendem a essa população, bem como a quem se dedica a estudá-la com mais profundidade. Primeiramente, isso se deve à dificuldade em se fechar o diagnóstico clínico e também em se estabelecer uma terapêutica medicamentosa eficaz, segura e permanente. Diferenças no padrão de ciclagem, predominância de fases mistas, gravidade das crises e a necessidade de se utilizar associações farmacológicas tornam o tratamento do transtorno bipolar de início precoce bastante complexo, exigindo uma gama maior de possibilidades terapêuticas. O caso apresentado relata a experiência com o uso da quetiapina em um paciente com o diagnóstico clínico de transtorno do humor bipolar de início na infância e adolescência, que começou aos 12 anos, e cuja resposta aos diferentes esquemas se mostrou insatisfatória. O uso da quetiapina mostrou-se eficaz no controle da crise e na estabilização do humor neste caso.

          Translated abstract

          Bipolar disorder in children and adolescents has become a great challenge for professionals who work with this type of patients, as well as for researchers interested in studying it in depth. Firstly, diagnostic assessment is difficult; secondly, to establish a safe, long-term and effective treatment is challenging. Different cycling patterns, predominance of mixed episodes, severity of symptoms and need of polypharmacy makes the treatment of child and adolescent bipolar disorder very complex and requiring a wider range of therapeutic resources. The present case reports a successful use of quetiapine for a bipolar adolescent diagnosed at the age of 12 years who had been unsuccessfully treated using many therapeutic options. Quetiapine showed efficacy in both acute and prophylactic treatment of early-onset bipolar disorder.

          Related collections

          Most cited references39

          • Record: found
          • Abstract: found
          • Article: not found

          Signs and symptoms of mania in pure and mixed episodes.

          Debate continues about the diagnosis of mixed mania and the restrictiveness of the DSM-III-R and DSM-IV criteria for Bipolar Disorder, mixed. Although awareness of dysphoric features during mania continues to grow, standard mania rating instruments do not adequately assess mixed states and there is a striking disparity between the dysphoric signs and symptoms emphasized in research studies and the commonly employed DSM criteria. Three hundred sixteen inpatients meeting DSM-III-R criteria for Bipolar Disorder, manic or mixed, were evaluated by rating 20 signs and symptoms. The frequencies of these signs and symptoms were computed for both diagnostic subtypes and compared using chi2 statistics and conditional probability parameters. The most frequently noted signs and symptoms in mania are motor activation, accelerated thought process, pressured speech and decreased sleep. Although euphoric mood was present in a large portion of the cohort, irritability, dysphoric mood and mood lability were also prominent in the entire cohort. Dysphoric mood, mood lability, anxiety, guilt, suicidality, and irritability were the only symptoms significantly more common in the mixed group. In contrast, grandiosity, euphoric mood, and pressured speech were significantly more often observed in the pure manic group. Contrary to popular belief, paranoia did not differ significantly between the two groups. Suicidality was present in a non-trivial 7% of the entire cohort, including some subjects who did not meet the criteria for mixed mania. The comparison of mixed and manic episodes requires the appropriate definition of mixed states. In the current report we use the DSM-III-R definition of Bipolar Disorder, mixed, which may be too rigid. The data underscore that mania is not a purely euphoric state. Substantial rates of dysphoria, lability, anxiety and irritability were noted in the "pure" manic patients, as well as in those who meet the full DSM criteria for Bipolar Disorder, mixed, suggesting, that perhaps a less restrictive definition of mixed states would be more appropriate.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Age of onset in bipolar affective disorder and misdiagnosis as schizophrenia.

            The age of onset in bipolar affective disorder was determined in 200 hospitalized patients. The mean age of their first affective syndrome was 28.3 years, and the mean age of first hospitalization was 30.8 years. However, the median age for first affective syndrome was 23 years (26 years for first hospitalization), and the most common age of onset was 15-19 years. Those patients with an early onset, especially if they were first hospitalized for mania, were most likely to have received a diagnosis of schizophrenia.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Age at Onset of Bipolar Affective Illness

                Bookmark

                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Journal
                rprs
                Revista de Psiquiatria do Rio Grande do Sul
                Rev. psiquiatr. Rio Gd. Sul
                Sociedade de Psiquiatria do Rio Grande do Sul (Porto Alegre )
                0101-8108
                December 2006
                : 28
                : 3
                : 346-351
                Affiliations
                [1 ] Universidade de São Paulo Brazil
                [2 ] Universidade de São Paulo Brazil
                Article
                S0101-81082006000300014
                10.1590/S0101-81082006000300014
                dbfa6abd-63f0-4845-af37-b3aeaf7045b2

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0101-8108&lng=en
                Categories
                ACOUSTICS
                PSYCHIATRY

                Clinical Psychology & Psychiatry,Acoustics
                Bipolar disorder,quetiapine,adolescent,treatment,Transtorno bipolar,quetiapina,adolescente,tratamento

                Comments

                Comment on this article