Adrenal Function in Rats Given PMS Before Puberty: Response to Ether Stress

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Abstract

This study reports the effects of precociously inducedpuberty upon basal serum corticosterone levels and the response to ether stress (ES) in maturing female rats. Precocious puberty was produced by 25 IU pregnant mare’s serum gonadotrophin (PMS) given at 9 a.m. to 26-day-old rats. On days 28 and 30 PMS-treated rats had higher resting values of corticosterone (B) than did saline-treated rats. On day 35, resting B was greatly depressed in PMS-treated rats in comparison to normal controls. On day 28 the response to ES was less sustained in PMS-treated rats whereas at 35 days of age it was very depressed at all time intervals. Ovariectomy at 21 days of age prevented the post-ovulatory depression of basal and stress-evoked serum B after PMS. It is concluded that the onset of puberty stimulates adrenal function and that after ovulation the PMS-stimulated ovary suppresses adrenal function.

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Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1974

Publication date (Print): 1974

Publication date (Electronic): 20 March 2008

Volume: 14

Issue: 1

Pages: 1-13

Affiliations

University of Nebraska Medical Center and Indiana University

Article

Publisher ID: 122240 Other ID: Neuroendocrinology 1974;14:1–13

DOI: 10.1159/000122240

PubMed ID: 4858310

SO-VID: dc06ca8f-1923-40e4-b7fd-1c17e6a17420

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 03 April 1973

Date accepted : 25 June 1973

Page count

Pages: 13

Adrenal Function in Rats Given PMS Before Puberty: Response to Ether Stress

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Karger: Endocrinology

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