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      Adrenal Function in Rats Given PMS Before Puberty: Response to Ether Stress

      ,

      Neuroendocrinology

      S. Karger AG

      Puberty, Adrenal function, Stress, PMS

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          Abstract

          This study reports the effects of precociously inducedpuberty upon basal serum corticosterone levels and the response to ether stress (ES) in maturing female rats. Precocious puberty was produced by 25 IU pregnant mare’s serum gonadotrophin (PMS) given at 9 a.m. to 26-day-old rats. On days 28 and 30 PMS-treated rats had higher resting values of corticosterone (B) than did saline-treated rats. On day 35, resting B was greatly depressed in PMS-treated rats in comparison to normal controls. On day 28 the response to ES was less sustained in PMS-treated rats whereas at 35 days of age it was very depressed at all time intervals. Ovariectomy at 21 days of age prevented the post-ovulatory depression of basal and stress-evoked serum B after PMS. It is concluded that the onset of puberty stimulates adrenal function and that after ovulation the PMS-stimulated ovary suppresses adrenal function.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1974
          1974
          20 March 2008
          : 14
          : 1
          : 1-13
          Affiliations
          University of Nebraska Medical Center and Indiana University
          Article
          122240 Neuroendocrinology 1974;14:1–13
          10.1159/000122240
          4858310
          © 1974 S. Karger AG, Basel

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          Page count
          Pages: 13
          Categories
          Paper

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