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      Adhesion proteins on human microglial cells and modulation of their expression by IL1 alpha and TNF alpha.

      1 , , ,
      Research in virology

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          Abstract

          Expression of adhesion proteins on human microglial cells was studied by immunocytochemistry. Both microglial cells and peripheral blood monocytes expressed beta 2 integrins and molecules of the immunoglobulin superfamily at similar levels whereas the expression of the beta 1 integrins (alpha 2-VLA (very late antigen), alpha 4-VLA, alpha 5-VLA, alpha 6-VLA) was higher on microglial cells than on monocytes. Stimulation of microglial cells with interleukin-1 alpha and tumour necrosis factor-alpha, the main cytokines detected in HIV1-infected central nervous system (CNS), increased the microglial expression of alpha 1-VLA, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and beta 2-LFA-1 (leukocyte-function-associated molecule-1) but not of alpha L-LFA-1. Such an induction of adhesion molecules could facilitate penetration of HIV1-infected monocytes into brain parenchyma and their adhesion to CNS cells, and could maintain a chronic inflammation during human immunodeficiency virus-1 (HIV1) encephalopathy.

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          Author and article information

          Journal
          Res. Virol.
          Research in virology
          0923-2516
          0923-2516
          January 1 1993
          : 144
          : 1
          Affiliations
          [1 ] Laboratoire de Neurovirologie et Neuroimmunologie, Université Paris XI, UFR Kremlin-Bicêtre.
          Article
          8446777
          dc0de16f-2c67-418c-a6f0-e6b871df841b
          History

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