+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Effects of Ocular Hypotensive Agents on Prostaglandin-Mediated Elevation of Intraocular Pressure

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Marked vasodilation followed by a rupture of the blood aqueous barrier is the best-documented hypothesis to explain the rise of intraocular pressure (IOP) induced by prostaglandins (PGs) or their precursors. However, a direct action on secretory mechanisms in the ciliary processes may not be excluded. To explore the latter possibility, compounds capable of decreasing IOP by different mechanisms have been tested in rabbits for their effects on experimentally elevated IOP induced by arachidonic acid (AA) and PGE<sub>2</sub>. Topical administration of 50 μ1of 0.5% AA or 0.01% PGE<sub>2</sub> solutions was utilized as standard ocular hypertensive doses. Epinephrine, norepinephrine, phenylephrine and isoproterenol administered topically and acetazolamide administered orally were tested for their effects on the IOP response to AA and PGE<sub>2</sub>. The IOP elevation due to AA instillation was studied at 30 min and 4 h after administration of the test agents. Only one experimental time (30 min) was used for PGE<sub>2</sub> to confirm the data obtained with AA. At 30 min, α- and mixed αβ-adrenerig agonists inhibited in a dose-related manner the PG-mediated elevation of IOP. In contrast, they did not affect these reactions at 4 h when their ocular hypotensive effect was maximal. The β-adrenergic agonist and acetazolamide did not influence AA or PG responses at either experimental time. The inhibition observed with epinephrine, norepinephrine and phenylephrine was attributed to their vasoconstrictive properties rather than to an effect on aqueous humor secretory mechanisms. These results argue against the formulated hypothesis that PGs elevate IOP by a direct action on secretory mechanism and give additional evidence for a vascular effect of PGs on the eye.

          Related collections

          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 10
          : 4
          : 202-211
          MSD-Chibret, Clermont-Ferrand
          264957 Ophthalmic Res 1978;10:202–211
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10


          Comment on this article