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      Silicosis en trabajadores expuestos a conglomerados de cuarzo Translated title: Silicosis in workers exposed to quartz conglomerates

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          Abstract

          Resumen Introducción: la silicosis, enfermedad crónica, causada por la inhalación de polvo de sílice cristalina, sigue siendo un problema de salud laboral vigente. El objetivo de la investigación consistió en estimar el riesgo de silicosis complicada y/o acelerada en trabajadores expuestos a polvo de sílice de conglomerados de cuarzo frente al riesgo de los trabajadores expuestos a roca ornamental. Método: se desarrolló un estudio analítico de casos y controles prevalentes en trabajadores cuya vigilancia de la salud se realizó en el instituto Nacional de Silicosis (España), entre el 1 de enero de 2008 y el 31 de diciembre de 2018 (N = 90). El valor de la significación de todos los contrastes de hipótesis realizados fue α = 0,05. Resultados: se determinó mayor riesgo de silicosis complicada en los trabajadores expuestos a polvo de sílice proveniente del uso de conglomerados de cuarzo mediante el cálculo de Chi cuadrado, con un total de 7 casos (46,67%) de silicosis complicada (p = 0,046). Conclusiones: existe mayor riesgo de silicosis complicada en los trabajadores expuestos a polvo de sílice proveniente del uso de conglomerados de cuarzo frente a los expuestos a polvo de sílice de roca ornamental. No se observó relación entre el riesgo de desarrollar silicosis acelerada y la exposición a conglomerados de cuarzo en la muestra analizada.

          Translated abstract

          Abstract Introduction: silicosis, a chronic disease caused by the inhalation of crystalline silica dust, continues to be a current occupational health problem. The objective of the research was to estimate the risk of complicated and/or accelerated silicosis in workers exposed to silica dust from quartz conglomerates compared to the risk of workers exposed to ornamental rock. Method: an analytical study of cases and controls prevalent in workers whose health surveillance was carried out at the National Institute of Silicosis (Spain), between January 1, 2008 and December 31, 2018 was developed (N = 90). The significance value of all the hypotheses tests performed was α = 0.05. Results: a higher risk of complicated silicosis was determined in workers exposed to silica dust from the use of quartz conglomerates by calculating Chi square, with a total of 7 cases (46.67%) of complicated silicosis (p = 0.046). Conclusions: there is a higher risk of complicated silicosis in workers exposed to silica dust from the use of quartz conglomerates compared to those exposed to silica dust from ornamental rock. No relationship was observed between the risk of developing accelerated silicosis and exposure to quartz conglomerates in the analyzed sample.

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          Most cited references19

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          Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

          Summary Background Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. Methods We estimated cause-specific deaths and years of life lost (YLLs) by age, sex, geography, and year. YLLs were calculated from the sum of each death multiplied by the standard life expectancy at each age. We used the GBD cause of death database composed of: vital registration (VR) data corrected for under-registration and garbage coding; national and subnational verbal autopsy (VA) studies corrected for garbage coding; and other sources including surveys and surveillance systems for specific causes such as maternal mortality. To facilitate assessment of quality, we reported on the fraction of deaths assigned to GBD Level 1 or Level 2 causes that cannot be underlying causes of death (major garbage codes) by location and year. Based on completeness, garbage coding, cause list detail, and time periods covered, we provided an overall data quality rating for each location with scores ranging from 0 stars (worst) to 5 stars (best). We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to generate estimates for each location, year, age, and sex. We assessed observed and expected levels and trends of cause-specific deaths in relation to the Socio-demographic Index (SDI), a summary indicator derived from measures of average income per capita, educational attainment, and total fertility, with locations grouped into quintiles by SDI. Relative to GBD 2015, we expanded the GBD cause hierarchy by 18 causes of death for GBD 2016. Findings The quality of available data varied by location. Data quality in 25 countries rated in the highest category (5 stars), while 48, 30, 21, and 44 countries were rated at each of the succeeding data quality levels. Vital registration or verbal autopsy data were not available in 27 countries, resulting in the assignment of a zero value for data quality. Deaths from non-communicable diseases (NCDs) represented 72·3% (95% uncertainty interval [UI] 71·2–73·2) of deaths in 2016 with 19·3% (18·5–20·4) of deaths in that year occurring from communicable, maternal, neonatal, and nutritional (CMNN) diseases and a further 8·43% (8·00–8·67) from injuries. Although age-standardised rates of death from NCDs decreased globally between 2006 and 2016, total numbers of these deaths increased; both numbers and age-standardised rates of death from CMNN causes decreased in the decade 2006–16—age-standardised rates of deaths from injuries decreased but total numbers varied little. In 2016, the three leading global causes of death in children under-5 were lower respiratory infections, neonatal preterm birth complications, and neonatal encephalopathy due to birth asphyxia and trauma, combined resulting in 1·80 million deaths (95% UI 1·59 million to 1·89 million). Between 1990 and 2016, a profound shift toward deaths at older ages occurred with a 178% (95% UI 176–181) increase in deaths in ages 90–94 years and a 210% (208–212) increase in deaths older than age 95 years. The ten leading causes by rates of age-standardised YLL significantly decreased from 2006 to 2016 (median annualised rate of change was a decrease of 2·89%); the median annualised rate of change for all other causes was lower (a decrease of 1·59%) during the same interval. Globally, the five leading causes of total YLLs in 2016 were cardiovascular diseases; diarrhoea, lower respiratory infections, and other common infectious diseases; neoplasms; neonatal disorders; and HIV/AIDS and tuberculosis. At a finer level of disaggregation within cause groupings, the ten leading causes of total YLLs in 2016 were ischaemic heart disease, cerebrovascular disease, lower respiratory infections, diarrhoeal diseases, road injuries, malaria, neonatal preterm birth complications, HIV/AIDS, chronic obstructive pulmonary disease, and neonatal encephalopathy due to birth asphyxia and trauma. Ischaemic heart disease was the leading cause of total YLLs in 113 countries for men and 97 countries for women. Comparisons of observed levels of YLLs by countries, relative to the level of YLLs expected on the basis of SDI alone, highlighted distinct regional patterns including the greater than expected level of YLLs from malaria and from HIV/AIDS across sub-Saharan Africa; diabetes mellitus, especially in Oceania; interpersonal violence, notably within Latin America and the Caribbean; and cardiomyopathy and myocarditis, particularly in eastern and central Europe. The level of YLLs from ischaemic heart disease was less than expected in 117 of 195 locations. Other leading causes of YLLs for which YLLs were notably lower than expected included neonatal preterm birth complications in many locations in both south Asia and southeast Asia, and cerebrovascular disease in western Europe. Interpretation The past 37 years have featured declining rates of communicable, maternal, neonatal, and nutritional diseases across all quintiles of SDI, with faster than expected gains for many locations relative to their SDI. A global shift towards deaths at older ages suggests success in reducing many causes of early death. YLLs have increased globally for causes such as diabetes mellitus or some neoplasms, and in some locations for causes such as drug use disorders, and conflict and terrorism. Increasing levels of YLLs might reflect outcomes from conditions that required high levels of care but for which effective treatments remain elusive, potentially increasing costs to health systems. Funding Bill & Melinda Gates Foundation.
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            Silica‐related diseases in the modern world

            Silicosis is an ancient and potentially fatal pneumoconiosis caused by exposure to respirable crystalline silica. Silicosis is historically a disease of miners; however, failure to recognize and control the risk associated with silica exposure in contemporary work practices such as sandblasting denim jeans and manufacturing of artificial stone benchtops has led to re-emergence of silicosis around the world. This review outlines the mineralogy, epidemiology, clinical and radiological features of the various forms of silicosis and other silica-associated diseases. Perspective is provided on the most recent studies shedding light on pathogenesis, including the central role of innate immune effector cells and subsequent inflammatory cascades in propagating pulmonary fibrosis and the extrapulmonary manifestations, which uniquely characterize this pneumoconiosis. Clinical conundrums in differential diagnosis, particularly between silicosis and sarcoidosis, are highlighted, as is the importance of obtaining a careful occupational history in the patient presenting with pulmonary infiltrates and/or fibrosis. While silicosis is a completely preventable disease, unfortunately workers around the world continue to be affected and experience progressive or even fatal disease. Although no treatments have been proven, opportunities to intervene to prevent progressive disease, founded in a thorough cellular and molecular understanding of the immunopathology of silicosis, are highlighted.
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              Artificial Stone Associated Silicosis: A Systematic Review

              Silicosis is a progressive fibrotic lung disease that is caused by the inhalation of respirable crystalline silica. Due to its high silica content, artificial stone (AS) can become a possible source of hazardous dust exposure for workers that are employed in the manufacturing, finishing, and installing of AS countertops. Therefore, the aim of this review was to verify the association between AS derived silica exposure and silicosis development, and also then define the pathological characteristics of the disease in relation to specific work practices and preventive and protective measures that were adopted in the workplace. A systematic review of articles available on Pubmed, Scopus, and Isi Web of Knowledge databases was performed. Although the characteristics of AS-associated silicosis were comparable to those that were reported for the disease in traditional silica exposure settings, some critical issues emerged concerning the general lack of suitable strategies for assessing/managing silica risks in these innovative occupational fields. Further research that is designed to assess the hazardous properties of AS dusts, levels of exposure in workplaces, and the effectiveness of protective equipment appears to be needed to increase awareness concerning AS risks and induce employers, employees, and all factory figures that are engaged in prevention to take action to define/adopt proper measures to protect the health of exposed workers.
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                Author and article information

                Journal
                mesetra
                Medicina y Seguridad del Trabajo
                Med. segur. trab.
                Escuela Nacional de Medicina del Trabajo. Instituto de Salud Carlos III (Madrid, Madrid, Spain )
                0465-546X
                1989-7790
                March 2022
                : 68
                : 266
                : 11-24
                Affiliations
                [6] Madrid orgnameInstituto de Salud Carlos III orgdiv1Escuela Nacional de Medicina del Trabajo España
                [2] Oviedo orgnameHospital Universitario Central de Asturias orgdiv1Servicio de Prevención de Riesgos Laborales España
                [4] Madrid orgnameHospital Clínico San Carlos orgdiv1Servicio de prevención de riesgos laborales España
                [3] Logroño orgnameServicio Riojano de Salud orgdiv1Hospital San Pedro orgdiv2Servicio de Prevención de Riesgos Laborales España
                [7] Madrid orgnameInstituto Nacional de Seguridad y Salud en el Trabajo España
                [1] Bilbao orgnameHospital Universitario Basurto orgdiv1Unidad Básica de Prevención España
                Article
                S0465-546X2022000100011 S0465-546X(22)06826600011
                10.4321/s0465-546x2022000100002
                dc19c5c7-271b-4d2a-bf58-c94d29a3b142

                This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

                History
                : 28 January 2022
                : 27 January 2022
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 20, Pages: 14
                Product

                SciELO Spain

                Categories
                Originales

                silicosis,cuarzo,conglomerados de cuarzo,piedra artificial,roca ornamental,silicosis complicada,silicosis acelerada,quartz,quartz conglomerates,artificial stone,ornamental rock,complicated silicosis,accelerated silicosis

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