16
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Potential Effects of Nichi Glucan as a Food Supplement for Diabetes Mellitus and Hyperlipidemia: Preliminary Findings from the Study on Three Patients from India

      case-report

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Beta Glucan food supplements have been reported to be of benefit in diabetes and hyperlipidemia. We report a pilot study of the effects of Nichi Glucan, 1, 3-1, 6 Beta Glucan food supplement, in lowering the blood glucose and lipid levels in three patients with noninsulin-dependent diabetes mellitus (NIDDM) from India. These patients had increased blood glucose and lipid levels inspite of routine antidiabetic and lipid level lowering medications. Each of the participants took 1.5 g of Nichi Glucan per day with food for two months along with their routine medications. The relevant parameters to assess glycemic status and lipid levels were calculated at the baseline and at the end of two months. After two months of continuous consumption, in one patient, the HbA1c decreased from 9.1% to 7.8%, and the glycemic target of HbA1c <6.5% laid down by the International Diabetes Federation was reached in two patients. Lipid levels also decreased significantly. Based on our findings, Nichi Glucan food supplement can be considered along with routine medications in patients with Type II diabetes with hyperlipidemia. Further studies are needed to validate the results.

          Related collections

          Most cited references13

          • Record: found
          • Abstract: not found
          • Article: not found

          Epidemiologic and economic consequences of the global epidemics of obesity and diabetes.

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Beta-glucans in the treatment of diabetes and associated cardiovascular risks

            Diabetes mellitus is characterized by high blood glucose level with typical manifestations of thirst, polyuria, polydipsia, and weight loss. It is caused by defects in insulin-mediated signal pathways, resulting in decreased glucose transportation from blood into muscle and fat cells. The major risk is vascular injury leading to heart disease, which is accelerated by increased lipid levels and hypertension. Management of diabetes includes: control of blood glucose level and lipids; and reduction of hypertension. Dietary intake of beta-glucans has been shown to reduce all these risk factors to benefit the treatment of diabetes and associated complications. In addition, beta-glucans also promote wound healing and alleviate ischemic heart injury. However, the mechanisms behind the effect of beta-glucans on diabetes and associated complications need to be further studied using pure beta-glucan.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Why are Indians more prone to diabetes?

              Diabetes, a global public health problem, is now emerging as a pandemic and by the year 2025, three-quarters of the world's 300 million adults with diabetes will be in non-industrialized countries and almost a third in India and China alone. There is evidence from several studies that the prevalence of Type 2 diabetes is increasing in migrant Indians. Today, the prevalence of diabetes in the urban metros of India is approaching the figures reported in the affluent migrant Indians. Environmental and lifestyle changes resulting from industrialization and migration to urban environment from rural settings may be responsible to a large extent, for this epidemic of Type 2 diabetes in Indians. Obesity, especially central obesity and increased visceral fat due to physical inactivity, and consumption of a high-calorie/high-fat and high sugar diets are major contributing factors. There is also strong evidence that Indians have a greater degree of insulin resistance and a stronger genetic predisposition to diabetes. As several of the factors associated with diabetes are potentially modifiable, this epidemic of diabetes can be curbed if proper measures are taken to increase physical activity and reduce obesity rates in adults, and most importantly, in children. In addition, strategies to achieve healthy fetal and infant growth and encouraging the use of traditional diets rich in fibre are also important steps. Such interventions should be attempted in those who are genetically predisposed to diabetes in order to tackle the explosion of, and thereby reduce the burden due to, diabetes within the Indian subcontinent.
                Bookmark

                Author and article information

                Journal
                Case Report Med
                Case Report Med
                CRIM
                Case Reports in Medicine
                Hindawi Publishing Corporation
                1687-9627
                1687-9635
                2012
                10 December 2012
                : 2012
                : 895370
                Affiliations
                1Division of Translational Medicine, Nichi-In Centre for Regenerative Medicine (NCRM), PB 2278, Tamil Nadu, Chennai 600094, India
                2Arogya Siddha Hospital, A-2 Alankar Plaza, 425 Kilpauk Garden Main Road, Chennai 600 010, India
                3Kingwood Psychiatry, 19701 Kingwood Dr., Building No. 3, Kingwood, TX 77339, USA
                4Hope Foundation (Trust), B6, 13, Zakariah colony III St., Choolaimedu, Chennai 600094, India
                5Department of Clinical Research, School of Medicine, University of Yamanashi, 1110, Shimokato, Yamanashi, Chuo 409-3898, Japan
                Author notes
                *Samuel J. K. Abraham: drabrahamsj@ 123456ybb.ne.jp

                Academic Editor: Peter E. H. Schwarz

                Article
                10.1155/2012/895370
                3529881
                23304164
                dc2bac97-6e01-409d-badf-159d25691440
                Copyright © 2012 Vidyasagar Devaprasad Dedeepiya et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 5 July 2012
                : 15 November 2012
                Categories
                Case Report

                Medicine
                Medicine

                Comments

                Comment on this article