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      Effects of Recombinant Human Growth Hormone on Height and Skeletal Maturation in Growth Hormone-Deficient Children with and without Severe Pretreatment Bone Age Delay

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          The relative effects of growth hormone (GH) on GH-deficient (GHD) children with and without severely delayed skeletal maturation prior to treatment are unclear. Methods: Pre-pubertal GHD children enrolled in the National Cooperative Growth Study were divided into two groups: severe pretreatment BA delay (BA Z-score ≤–2, group 1) and mild to moderate delay (BA Z-score between –2 and 0, group 2). BA Z-scores (BAZ), height Z-scores and predicted adult height (PAH) Z-scores at pubertal onset were determined after initiation of recombinant human GH (rhGH) therapy. Results: Height Z-scores increased from baseline to the start of puberty in both groups (group 1: mean difference of +0.99, males and +1.02, females; group 2: +0.68, males and +0.75, females). Mean BAZ also increased in all group 1 children (+1.62, males and +1.08, females) with no corresponding change in mean BAZ in group 2. PAH Z-scores increased in both groups. There was no evidence of undue advance in BA since mean BAZ remained well below zero in group 1 and was unchanged in group 2. Conclusion: rhGH has a beneficial effect on growth in prepubertal GHD children at all levels of pretreatment BA delay.

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          Factors predicting the response to growth hormone (GH) therapy in prepubertal children with GH deficiency

           S L Blethen (1993)

            Author and article information

            Horm Res Paediatr
            Hormone Research in Paediatrics
            S. Karger AG
            January 1999
            31 March 1999
            : 51
            : 1
            : 15-19
            aDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Ark., and bDepartment of Medical Affairs, Genentech, Inc., South San Francisco, Calif., USA
            23307 Horm Res 1999;51:15–19
            © 1999 S. Karger AG, Basel

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            Figures: 2, Tables: 2, References: 14, Pages: 5
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