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      Pharmacokinetics and distribution of a fluoresceinated glycosaminoglycan, sulodexide, in rats. Part I: Pharmacokinetics in rats.

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      Arzneimittel-Forschung

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          Abstract

          Fluorescein-labelled sulodexide pharmacokinetics and urinary excretion were studied in the rat after intravenous administration. The compound showed a pharmacokinetic pattern similar to that of heparin and the plasmatic levels were linearly correlated with anti-factor Xa activity and logarithmically with lipoprotein lipase activation. The compound is well eliminated by urinary route; the urinary recovery was 50% in 24 h and 67% 48 h after administration. The results obtained indicate that fluorescein labelling of glycosaminoglycans may be a valid tool for pharmacokinetics and distribution studies in the laboratory animals.

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          Author and article information

          Journal
          Arzneimittelforschung
          Arzneimittel-Forschung
          0004-4172
          0004-4172
          1985
          : 35
          : 10
          Article
          4074405
          dc5192a3-a4e5-4620-b052-9e178f8ca523
          History

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