Diversity in AMPA receptor complexes in the brain.

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Abstract

AMPA receptor (AMPAR) complexes comprise four of the AMPAR subunits GluA1-4 and several additional interacting proteins. Subunit composition determines AMPAR function. However, AMPAR function depends to a large extent also on interacting proteins, which influence trafficking to the cell surface, activity-dependent subcellular localization and gating of AMPARs. In this review we report about recent findings on the diversity of AMPAR complexes that allow us to better understand functional properties of native receptors in the brain.

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Journal

Journal ID (iso-abbrev): Curr. Opin. Neurobiol.

Title: Current opinion in neurobiology

Publisher: Elsevier BV

ISSN (Electronic): 1873-6882

ISSN (Print): 0959-4388

Publication date (Electronic): Aug 2017

Volume: 45

Affiliations

[1 ] Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

[2 ] Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address: engelhardt@uni-mainz.de.

Article

Publisher Item ID: S0959-4388(16)30184-2

DOI: 10.1016/j.conb.2017.03.001

PubMed ID: 28376410

SO-VID: dc5f5285-34a2-4936-87a8-619d57c93a1e

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