• Record: found
  • Abstract: found
  • Article: not found

Laboratory assessment of the anticoagulant effects of the next generation of oral anticoagulants.

Read this article at

      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


      In contrast to vitamin K antagonists, which reduce the functional levels of several coagulation factors, the new oral anticoagulants specifically target either thrombin or factor Xa. These new agents have such predictable pharmacokinetics and pharmacodynamics that routine coagulation monitoring is unnecessary. However, there are still some situations in which measurement of anticoagulant effect may be required. The coagulation assays that are used to monitor heparin derivatives or vitamin K antagonists may not always accurately reflect the anticoagulant activity of the new oral anticoagulants, and specialized assays may be needed. In this article, we: (i) identify situations in which assessment of anticoagulant effect may aid treatment decisions; (ii) describe the effects of the new oral anticoagulants on the various coagulation tests; (iii) review the specialized coagulation assays that have been developed to measure the anticoagulant effects of the new oral anticoagulants; and (iv) provide a clinical perspective on the role of coagulation testing in the clinical management of patients treated with the new oral anticoagulants.

      Related collections

      Author and article information

      [1 ] University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
      J. Thromb. Haemost.
      Journal of thrombosis and haemostasis : JTH
      Feb 2013
      : 11
      : 2
      23216682 10.1111/jth.12096
      © 2012 International Society on Thrombosis and Haemostasis.


      Comment on this article