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      Effects of Mydriatic Agents on Neutrophil Migration

      research-article
      , ,
      Ophthalmic Research
      S. Karger AG
      Chemokinesis, Chemotaxis, Cyclopentolate, Mydriatic agents, Uveitis

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          Abstract

          We have investigated the effects of various mydriatic agents on the locomotion of polymorphonuclear leukocytes in vitro. Human as well as rat neutrophils showed a dose dependent increase of migration into micropore filters when tested against cyclopentolate hydrochloride at a dose range between 16 and 63 μg/ml. At higher doses (250 μg/ml), a complete inhibition of neutrophil migration was observed. A commercially available cyclopentolate hydrochloride preparation showed identical effects. Little or no changes in neutrophil locomotion were seen with atropine, homatropine, scopolamine or tropicamide when tested at the same concentration range. Since addition of cyclopentolate to either the lower or upper compartment of the multiwell chemotaxis chamber gave virtually the same results, it is assumed that the drug most likely induces a chemokinetic neutrophil response. However, an additional chemotactic effect cannot be excluded. These in vitro observations may help to explain an accidental observation in a patient with severe anterior uveitis who showed a massive, localized leukocyte accumulation on the corneal endothelium after contact with a cyclopentolate-soaked cotton pledget.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1988
          1988
          09 December 2009
          : 20
          : 1
          : 14-19
          Affiliations
          Department of Pathology, University of Michigan Medical School, Ann Arbor, Mich. USA; Department of Ophthalmology, Georgetown Medical School, Washington, D.C., USA
          Article
          266250 Ophthalmic Res 1988;20:14–19
          10.1159/000266250
          3380523
          dc754f2f-34d4-4467-80b4-fafd679277d3
          © 1988 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 30 October 1986
          : 21 August 1987
          Page count
          Pages: 6
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Chemotaxis,Mydriatic agents,Cyclopentolate,Uveitis,Chemokinesis

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