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      Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis.

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          Abstract

          Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future. This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance.

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          Author and article information

          Journal
          World J Gastroenterol
          World journal of gastroenterology
          Baishideng Publishing Group Inc.
          1007-9327
          1007-9327
          Jul 21 2008
          : 14
          : 27
          Affiliations
          [1 ] Department of Hepatology and Gastroenterology, Imperial College London, St Mary's Hospital Campus, Praed Street, London W2 1NY, United Kingdom.
          Article
          10.3748/wjg.14.4300
          2731180
          18666317
          dc8abc2d-2783-45a0-a30e-9e4ffee76f8e
          History

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