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      Dual targeting of mTOR and aurora-A kinase for the treatment of uterine Leiomyosarcoma.

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          Abstract

          The significance of mTOR activation in uterine leiomyosarcoma (ULMS) and its potential as a therapeutic target were investigated. Furthermore, given that effective therapies likely require combination mTOR blockade with inhibition of other targets, coupled with recent observations suggesting that Aurora-A kinase (Aurk-A) deregulations commonly occur in ULMS, the preclinical impact of dually targeting both pathways was evaluated.

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          Author and article information

          Journal
          Clin. Cancer Res.
          Clinical cancer research : an official journal of the American Association for Cancer Research
          1078-0432
          1078-0432
          Sep 1 2012
          : 18
          : 17
          Affiliations
          [1 ] Department of Cancer Biology, MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1104, Houston TX 77030, USA.
          Article
          1078-0432.CCR-12-0436 NIHMS394941
          10.1158/1078-0432.CCR-12-0436
          3432751
          22821997
          dc8cdf79-9f15-48cd-936e-584fc1397d17
          ©2012 AACR.
          History

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