P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

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Journal

Title: ACS Catalysis

Abbreviated Title: ACS Catal.

Publisher: American Chemical Society (ACS)

ISSN (Print): 2155-5435

ISSN (Electronic): 2155-5435

Publication date Created: March 08 2018

Publication date Created: April 06 2018

Publication date (Electronic): March 08 2018

Publication date (Print): April 06 2018

Volume: 8

Issue: 4

Pages: 3395-3410

Affiliations

[1 ]Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Muelheim, Germany

[2 ]Department of Chemistry, Philipps-University, Hans-Meerwein-Strasse 4, 35032 Marburg, Germany

[3 ]Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, Manchester M1 7DN, U.K.

[4 ]Centre for Computational Chemistry, School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, U.K.

[5 ]Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University 368 Youyi Road, Wuchang Wuhan 430062, China

[6 ]Department of Statistics, University of Haifa, Haifa 31905, Israel

Article

DOI: 10.1021/acscatal.8b00389

SO-VID: dc8f5ede-1782-4d0d-81cd-27c663126eb5

License:

http://pubs.acs.org/page/policy/authorchoice_termsofuse.html

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