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      The Clinical Characteristics and Outcomes of Diabetes Mellitus and Secondary Hyperglycaemia Patients with Coronavirus Disease 2019: a Single‐center, Retrospective, Observational Study in Wuhan

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          Abstract

          Aims

          Since the pandemic outbreak of COVID‐19, limited information is available on diabetic patients with COVID‐19.

          Materials and methods

          We retrospectively analysed 166 COVID‐19 patients at Tongji Hospital (Wuhan) from February 8 to March 21, 2020. Clinical characteristics and outcomes (as of April 4, 2020) were compared among control (group 1), secondary hyperglycaemia (group 2: no diabetes history, FPG levels ≥7.0 mmol/L once and HbA1c values <6.5%) and diabetic (group 3) patients.

          Results

          Compared to group 1, groups 2 and 3 had higher rates of leukocytosis, neutrophilia, lymphocytopenia, eosinopenia, and levels of sCRP, ferritin and d‐dimer ( P < 0.05 for all). Group 2 patients have higher levels of LDH, prevalence of liver dysfunction and increased IL‐8 than those in group 1, a higher prevalence of increased IL‐8 was found in group 2 than in group 3 ( P < 0.05 for all). The proportions of critical patients in groups 2 and 3 were significantly higher compared to group 1 (38.1%, 32.8% vs. 9.5%, P < 0.05 for both). Groups 2 and 3 had significantly longer hospital stays than group 1, which was nearly one week longer. The composite outcomes risks were 5.47 (1.56–19.82) and 2.61 (0.86–7.88) times greater in group 2 and 3 than in group 1.

          Conclusions

          Hyperglycemia in both diabetes and secondary hyperglycemia patients with COVID‐19 may indicate poor prognoses. There were differences between secondary hyperglycemia and diabetes patients. We recommend that clinicians pay more attention to the blood glucose status of COVID‐19 patients, even those not diagnosed with diabetes before admission.

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          Author and article information

          Contributors
          bjgaoying@yahoo.com
          Journal
          Diabetes Obes Metab
          Diabetes Obes Metab
          10.1111/(ISSN)1463-1326
          DOM
          Diabetes, Obesity & Metabolism
          Blackwell Publishing Ltd (Oxford, UK )
          1462-8902
          1463-1326
          14 May 2020
          : 10.1111/dom.14086
          Affiliations
          [ 1 ] Endocrinology Department of Peking University First Hospital Beijing China
          [ 2 ] Respiratory and Critical Care Medicine Department of Peking University First Hospital Beijing China
          [ 3 ] Geriatrics Department of Peking University First Hospital Beijing China
          Author notes
          [*] [* ] Correspondence

          Email: bjgaoying@ 123456yahoo.com

          Author information
          https://orcid.org/0000-0002-9156-9483
          Article
          DOM14086 DOM-20-0418-FT.R2
          10.1111/dom.14086
          7273002
          32406594
          dcaa1616-f8e3-4782-bf2c-b5fb2dffa92b
          This article is protected by copyright. All rights reserved.

          This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

          History
          : 17 April 2020
          : 08 May 2020
          : 08 May 2020
          Page count
          Figures: 0, Tables: 3, Pages: 1, Words: 8500
          Categories
          Original Article
          Original Articles
          Custom metadata
          2.0
          accepted-manuscript
          Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.3 mode:remove_FC converted:05.06.2020

          Endocrinology & Diabetes
          Endocrinology & Diabetes

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