EMT and MET in metastasis: where are the cancer stem cells?

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Abstract

Activation of epithelial-mesenchymal transition (EMT) is important for cancer cell dissemination. Two papers in this issue of Cancer Cell (Ocaña and colleagues and Tsai and colleagues) support the concept that the reversal of EMT is necessary for efficient metastatic colonization. Moreover, although EMT has been associated with stemness properties, one study indicates that they are not necessarily linked.

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Journal

Journal ID (iso-abbrev): Cancer Cell

Title: Cancer cell

Publisher: Elsevier BV

ISSN (Electronic): 1878-3686

ISSN (Print): 1535-6108

Publication date (Electronic): Dec 11 2012

Volume: 22

Issue: 6

Affiliations

[1 ] Department of General and Visceral Surgery, Comprehensive Cancer Center and BIOSS Centre for Biological Signalling Studies, University of Freiburg Medical Center, Hugstetter Str. 55, 79106 Freiburg, Germany. thomas.brabletz@uniklinik-freiburg.de

Article

Publisher Item ID: S1535-6108(12)00488-6

DOI: 10.1016/j.ccr.2012.11.009

PubMed ID: 23238008

SO-VID: dcd6e8c7-9dfa-441a-bd77-6cbe079f292c

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