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      Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma.

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          Abstract

          TH2 cells can further differentiate into dual-positive TH2/TH17 cells. The presence of dual-positive TH2/TH17 cells in the airways and their effect on asthma severity are unknown.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): J. Allergy Clin. Immunol.
          Title: The Journal of allergy and clinical immunology
          ISSN (Electronic): 1097-6825
          ISSN (Print): 0091-6749
          Publication date (Electronic): Nov 2014
          Volume: 134
          Issue: 5
          Affiliations
          [1 ] Department of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo.
          [2 ] Department of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo; School of Medicine, University of Colorado at Denver, Denver, Colo.
          [3 ] Department of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colo; School of Medicine, University of Colorado at Denver, Denver, Colo. Electronic address: alamr@njhealth.org.
          Article
          Publisher Item ID: S0091-6749(14)00799-4 Mid ID: NIHMS603405
          DOI: 10.1016/j.jaci.2014.05.038
          PMC ID: 4254017
          PubMed ID: 25042748
          SO-VID: dcdae337-a207-4039-a502-e16e4bd78d8a
          Copyright © Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
          History

          Keywords: Dual-positive T(H)2/T(H)17 cells,MEK,asthma,bronchoalveolar lavage,glucocorticoid resistance
          Data availability:
          Keywords: Dual-positive T(H)2/T(H)17 cells, MEK, asthma, bronchoalveolar lavage, glucocorticoid resistance

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