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      Prevalence of human papillomavirus infection of the anal canal in women: A prospective analysis of high-risk populations

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          Abstract

          Infection with certain types of human papillomavirus (HPV) has been associated with the development of cervical and anal cancer. Worldwide, the incidence of anal cancer has increased markedly. The present study aimed to evaluate the prevalence of HPV infection of the uterine cervix and anal canal in human immunodeficiency virus (HIV)- and non-HIV-infected risk populations. Cervical and anal HPV swabs and cytology samples were collected from 287 patients at the University Hospital of Munich, Germany between 2011 and 2013. Patients were divided into HIV-negative controls (G1) and two risk groups, including HIV-negative patients with cytological abnormalities of the cervix (G2) and HIV-infected patients (G3). Data, including clinical parameters, were analysed. The risk groups had significantly more positive results for HPV in the anus (71.03 and 83.15% for G2 and G3, respectively), as compared with G1. The predominant HPV genotypes found in the anus were high-risk HPV genotypes, which were significantly correlated with concomittant cervical HPV findings. In the risk groups, a significant association between the cytological findings and HPV detection in the cervix was found, while the results of the anus revealed no significance. The results of the present study suggested that the prevalence of HPV infection in the anal canal of risk populations is high. Furthermore, patients with abnormal cervical cytology results and HIV-infected women, irrespective of their individual cervical findings, may have a risk of concomittant anal high-risk HPV infection. Based on the predominant HPV genotypes found in the study, HPV vaccination could reduce the incidence of anal cancer. Nevertheless, high-risk patients should be intensively screened for anal squamous intraepithelial abnormalities to avoid invasive cancer stages.

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          Author and article information

          Journal
          Oncol Lett
          Oncol Lett
          OL
          Oncology Letters
          D.A. Spandidos
          1792-1074
          1792-1082
          April 2017
          10 February 2017
          10 February 2017
          : 13
          : 4
          : 2495-2501
          Affiliations
          [1 ]Department of Gynecology and Obstetrics, Ludwig-Maximilian University of Munich, D-80337 Munich, Germany
          [2 ]Institute of Medical Virology, Charité-Universitätsmedizin, D-10117 Berlin, Germany
          [3 ]STAT-UP Statistical Consulting and Services, D-80802 Munich, Germany
          [4 ]Department of Obstetrics and Gynecology, Charité-Universitätsmedizin, D-10117 Berlin, Germany
          Author notes
          Correspondence to: Dr Bernd P. Kost, Department of Gynecology and Obstetrics, Ludwig-Maximilian University of Munich, Maistrasse 11, D-80337 Munich, Germany, E-mail: bernd.kost@ 123456med.uni-muenchen.de
          Article
          PMC5403543 PMC5403543 5403543 OL-0-0-5714
          10.3892/ol.2017.5714
          5403543
          28454426
          dcde2740-fae7-4f2b-8938-8ef80a316bda
          Copyright © 2017, Spandidos Publications
          History
          : 19 July 2016
          : 23 November 2016
          Categories
          Articles

          human papillomavirus,human immunodeficiency virus,anal dysplasia,cancer screening,women

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