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      A single p450 allele associated with insecticide resistance in Drosophila.

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          Abstract

          Insecticide resistance is one of the most widespread genetic changes caused by human activity, but we still understand little about the origins and spread of resistant alleles in global populations of insects. Here, via microarray analysis of all P450s in Drosophila melanogaster, we show that DDT-R, a gene conferring resistance to DDT, is associated with overtranscription of a single cytochrome P450 gene, Cyp6g1. Transgenic analysis of Cyp6g1 shows that overtranscription of this gene alone is both necessary and sufficient for resistance. Resistance and up-regulation in Drosophila populations are associated with a single Cyp6g1 allele that has spread globally. This allele is characterized by the insertion of an Accord transposable element into the 5' end of the Cyp6g1 gene.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          1095-9203
          0036-8075
          Sep 27 2002
          : 297
          : 5590
          Affiliations
          [1 ] Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.
          Article
          297/5590/2253
          10.1126/science.1074170
          12351787
          dcf077bb-e699-413c-b32d-256a9138ee4d
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