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      Cytokines and T Cell Switching

      1 , 1
      Critical Reviews in Oral Biology & Medicine
      SAGE Publications

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          Abstract

          <p class="first" id="d23805571e55">In recent years, the phenotypic characterization of T cell subsets has given way to a functional dichotomy based essentially on their cytokine profiles. In this context, the CD4+ helper T cell subset has been shown to consist of two types, termed Th1 and Th2. In general, Th1 cells produce interleukin (IL)-2 and interferon (IFN)-gamma, while Th2 cells characteristically produce IL-4, IL-5, and IL-6. The major function of the Th1 subset is to mediate delayed-type hypersensitivity reactions and their secondary function is suppression of B cell activity. In contrast, the major function of the Th2 subset is to provide B cell help, while their secondary function is cell-mediated immune suppression. A similar dichotomy has also been described for CD8+ T cells. The role that these functional T cell subsets and their cytokines play in terms of their protective and nonprotective outcomes in a variety of infectious and oral diseases is reviewed. </p>

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          Author and article information

          Journal
          Critical Reviews in Oral Biology & Medicine
          Critical Reviews in Oral Biology & Medicine
          SAGE Publications
          1045-4411
          1544-1113
          December 2016
          September 1994
          December 2016
          September 1994
          : 5
          : 3
          : 249-279
          Affiliations
          [1 ]Immunopathology Laboratory, Oral Biology and Pathology, Department of Dentistry, The University of Queensland, Queensland 4072 Australia
          Article
          10.1177/10454411940050030301
          7535571
          dd0a2dbd-1ac1-4c06-9a96-0fff7f9f0111
          © 1994

          http://journals.sagepub.com/page/policies/text-and-data-mining-license

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