5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Modulation of rhythmogenic properties of trigeminal neurons contributing to the masticatory CPG.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Increasing evidence suggests that the dorsal part of the principal sensory nucleus of the trigeminal nerve (NVsnpr) contains a significant core of the central pattern generator (CPG) circuitry required for mastication (Tsuboi et al., 2003). Like many trigeminal brainstem neurons, those of NVsnpr are rhythmically active in phase with fictive mastication in vivo (Tsuboi et al., 2003) and project directly to the trigeminal motoneurons (Kolta et al., 2000), but in contrast with the others, they are the only neurons with intrinsic bursting abilities (Sandler et al., 1998; Brocard et al., 2006) within the minimal area of the brainstem necessary to produce rhythmic activity in trigeminal nerves (Bourque and Kolta, 2001). Development of bursting in NVsnpr neurons closely follows the development of mastication. It is mediated by a persistent Na(+) current (I(NaP)) that is expressed only within a certain membrane potential range and that is modulated by the extracellular Ca(2+) concentration ([Ca(2+)](e)), the lower the concentration, the larger the magnitude of I(NaP). Under physiological [Ca(2+)](e), bursting can also be induced in vitro by repetitive electrical stimulation of the trigeminal sensory tract, which projects massively to NVsnpr or by local applications of N-methyl-d-aspartic acid. Both types of stimuli also depolarize glial cells recorded in NVsnpr and increase coupling between them. Glial cells play a determinant role in setting [Ca(2+)](e) and hence are in a key position to influence NVsnpr neuronal firing pattern.

          Related collections

          Author and article information

          Journal
          Prog Brain Res
          Progress in brain research
          Elsevier BV
          1875-7855
          0079-6123
          2010
          : 187
          Affiliations
          [1 ] Faculté de médecine dentaire and Groupe de Recherche sur le Système Nerveux Central du FRSQ, Université deMontréal, Succursale Centre-ville, Montreal, Quebec, Canada.
          Article
          B978-0-444-53613-6.00009-5
          10.1016/B978-0-444-53613-6.00009-5
          21111205
          dd1f82a3-ec8b-4730-8ba6-e97ac8d865e8
          Copyright © 2010 Elsevier B.V. All rights reserved.
          History

          Comments

          Comment on this article