17
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP.

      1 , , ,
      Molecular medicine (Cambridge, Mass.)

      Read this article at

      ScienceOpenPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Several mouse strains expressing human islet amyloid polypeptide (IAPP) have been created to study development of islet amyloid and its impact on islet cell function. The tendency to form islet amyloid has varied strongly among these strains by factors that have not been elucidated. Because some beta cell granule components are known to inhibit IAPP fibril formation in vitro, we wanted to determine whether a mouse strain expressing human IAPP but lacking the nonamyloidogenic mouse IAPP is more prone to develop islet amyloidosis.

          Related collections

          Author and article information

          Journal
          Mol Med
          Molecular medicine (Cambridge, Mass.)
          1076-1551
          1076-1551
          Dec 2000
          : 6
          : 12
          Affiliations
          [1 ] Department of Biomedicine and Surgery, Linköping University, Sweden. gunwe@IBK.liu.se
          Article
          S1528365800209981
          1949926
          11474116
          dd2321bf-909f-4262-9ef7-ee7622aca716
          History

          Comments

          Comment on this article