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      Striatal dopamine in Parkinson disease: A meta-analysis of imaging studies.

      1 , 2 , 3 , 4 , 5
      Annals of neurology
      Wiley

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          Abstract

          A meta-analysis of 142 positron emission tomography and single photon emission computed tomography studies that have investigated striatal presynaptic dopamine function in Parkinson disease (PD) was performed. Subregional estimates of striatal dopamine metabolism are presented. The aromatic L-amino-acid decarboxylase (AADC) defect appears to be consistently smaller than the dopamine transporter and vesicular monoamine transporter 2 defects, suggesting upregulation of AADC function in PD. The correlation between disease severity and dopamine loss appears linear, but the majority of longitudinal studies point to a negative exponential progression pattern of dopamine loss in PD. Ann Neurol 2017;82:873-882.

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          Author and article information

          Journal
          Ann. Neurol.
          Annals of neurology
          Wiley
          1531-8249
          0364-5134
          Dec 2017
          : 82
          : 6
          Affiliations
          [1 ] Division of Clinical Neurosciences, Turku University Hospital.
          [2 ] Department of Neurology, University of Turku.
          [3 ] Turku PET Centre, University of Turku.
          [4 ] Departments of Clinical Medicine.
          [5 ] Biostatistics, University of Turku, Turku, Finland.
          Article
          10.1002/ana.25103
          29165839
          dd3683cb-58d0-4345-a77c-ffd484adac1b
          History

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