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      Thrombocytopenia in patients with severe acute respiratory syndrome (review).

      Hematology (Amsterdam, Netherlands)

      immunology, complications, Severe Acute Respiratory Syndrome, SARS Virus, virology, etiology, Purpura, Thrombocytopenic, Idiopathic, Lymphopenia, Lymphocyte Count, Humans, Hematopoietic Stem Cells

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          Abstract

          Severe Acute Respiratory Syndrome (SARS) has been recognized as a new human infectious disease caused by a novel coronavirus (SARS-CoV). Hematological changes in patients with SARS were common, including notably lymphopenia and thrombocytopenia. While the former is the result of decreases in CD4+ or CD8+ T-lymphocytes related to the onset of disease or use of glucocorticoids, the latter may involve a number of potential mechanisms. Although the development of autoimmune antibodies or immune complexes triggered by viral infection may play a significant role in inducing thrombocytopenia, SARS-CoV may also directly infect hematopoietic stem/progenitor cells, megakaryocytes and platelets inducing their growth inhibition and apoptosis. Moreover, the increased consumption of platelets and/or the decreased production of platelets in the damaged lungs are a potential alternative mechanism that can contribute to thrombocytopenia in severe critical pulmonary conditions, which has been rarely revealed and will be discussed.

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          Journal
          10.1080/10245330400026170
          16019455

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