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      Efficacy of milnacipran on the depressive state in patients with Alzheimer's disease.

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          Abstract

          An open-labeled study was conducted to examine the efficacy of selective serotonin and noradrenaline reuptake inhibitor (SNRI), milnacipran in treating depression in Alzheimer's disease (AD) patients. Eleven patients with AD showing major depressive symptoms were examined. Ten of 11 patients demonstrated an over 50% decrease in their HAM-D scores from the baseline, and 8 of 11 patients reached remission (HAM-D score<==7) within 12 weeks of the start of milnacipran treatment, and their GAF score was also remarkably improved. Although in 11 patients, two patients showed a mild hypomanic state and one patient showed daytime somnolence, these problems were quickly solved after a decrease in the daily dose or discontinuation of milnacipran. In addition, the treatment had no negative effects on cognitive function of the patients. Our study results suggest that milnacipran is a promising medicine for depressive state in AD patients.

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          Author and article information

          Journal
          Prog. Neuropsychopharmacol. Biol. Psychiatry
          Progress in neuro-psychopharmacology & biological psychiatry
          Elsevier BV
          0278-5846
          0278-5846
          Sep 30 2006
          : 30
          : 7
          Affiliations
          [1 ] Department of Psychiatry, Institute of Clinical Medicine University of Tsukuba, Japan, 1-1-1Tennodai, Tsukuba City, Ibaraki 305-8575, Japan. mizukami@md.tsukuba.ac.jp <mizukami@md.tsukuba.ac.jp>
          Article
          S0278-5846(06)00082-0
          10.1016/j.pnpbp.2006.03.004
          16603301
          dd40ac34-a70a-4505-9420-efbb10e0e2cd
          History

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