Sequential Mixed Lymphocyte Culture after Kidney Transplantation: Induction of Tolerance or Sensitization

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Abstract

Serial mixed lymphocyte culture (MLC) was used to monitor the evolution of donor-specific responsiveness over the first 2 years after cadaveric renal transplantation. Lymphocytes obtained from 37 patients at 0, 1, 3, 6, 12, 18 and 24 months following transplantation were assayed in a one-way MLC using donor lymphocytes as stimulator cells. Donor-specific hyporesponsiveness developed in 66% of the patients with functioning grafts. Donor-specific sensitization was noted in 2 patients with functioning grafts and the MLC reactivity remained unchanged compared to the pretransplant value in 8 patients. The patients with donor-specific hyporeactivity tended to remain either free of rejection episodes or experienced early rejection episodes only. Thus, using serial MLC we were able to identify patients who developed hyporeactivity or tolerance to donor antigens. These patients may require less immunosuppression.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1997

Publication date (Print): 1997

Publication date (Electronic): 19 December 2008

Volume: 75

Issue: 2

Pages: 166-170

Affiliations

Departments of ^aSurgery and ^bMedicine, University of Cape Town, and ^cProvincial Tissue Typing Laboratory, Cape Town, South Africa

Article

Publisher ID: 189526 Other ID: Nephron 1997;75:166–170

DOI: 10.1159/000189526

PubMed ID: 9041536

SO-VID: dd48e2a9-8b43-4211-9dff-fe2513825bc2

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Sequential Mixed Lymphocyte Culture after Kidney Transplantation: Induction of Tolerance or Sensitization

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Karger: Nephrology

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