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      Unconventional Use of Intense Pulsed Light

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          Abstract

          According to the literature, intense pulsed light (IPL) represents a versatile tool in the treatment of some dermatological conditions (i.e., pigmentation disorders, hair removal, and acne), due to its wide range of wavelengths. The authors herein report on 58 unconventional but effective uses of IPL in several cutaneous diseases, such as rosacea (10 cases), port-wine stain (PWS) (10 cases), disseminated porokeratosis (10 cases), pilonidal cyst (3 cases), seborrheic keratosis (10 cases), hypertrophic scar (5 cases) and keloid scar (5 cases), Becker's nevus (2 cases), hidradenitis suppurativa (2 cases), and sarcoidosis (1 case). Our results should suggest that IPL could represent a valid therapeutic support and option by providing excellent outcomes and low side effects, even though it should be underlined that the use and the effectiveness of IPL are strongly related to the operator's experience (acquired by attempting at least one specific course on the use of IPL and one-year experience in a specialized centre). Moreover, the daily use of these devices will surely increase clinical experience and provide new information, thus enhancing long-term results and improving IPL effectiveness.

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          Intense pulsed light (IPL): a review.

          Rolf-Markus Szeimies, Michael Landthaler, Philipp Babilas … (2010)
          Intense pulsed light (IPL) devices use flashlamps and bandpass filters to emit polychromatic incoherent high-intensity pulsed light of determined wavelength spectrum, fluence, and pulse duration. Similar to lasers, the basic principle of IPL devices is a more or less selective thermal damage of the target. The combination of prescribed wavelengths, fluences, pulse durations, and pulse intervals facilitates the treatment of a wide spectrum of skin conditions. To summarize the physics of IPL, to provide guidance for the practical use of IPL devices, and to discuss the current literature on IPL in the treatment of unwanted hair growth, vascular lesions, pigmented lesions, acne vulgaris, and photodamaged skin and as a light source for PDT and skin rejuvenation. A systematic search of several electronic databases, including Medline and PubMed and the authors experience on intense pulsed light. Numerous trials show the effectiveness and compatibility of IPL devices. Most comparative trials attest IPLs similar effectiveness to lasers (level of evidence: 2b to 4, depending on the indication). However, large controlled and blinded comparative trials with an extended follow-up period are necessary.
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            Treatment of rosacea with intense pulsed light: significant improvement and long-lasting results.

            Vassilios Papageorgiou, W Clayton, Christy S Norwood … (2008)
            Rosacea is a common skin condition but the treatments currently available are not satisfactory.
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              The use of acellular dermal matrix to prevent capsule formation around implants in a primate model.

              Amy Stump, Luther H. Holton, Jerome J. Connor … (2009)
              Implant-based breast reconstruction is a popular option after mastectomy, but capsular contracture may detract from long-term outcomes. The authors have observed that breast implants covered with acellular dermal matrix (AlloDerm) are less likely to develop a capsule in the area where the implant is in direct contact with the acellular matrix. The authors tested this observation experimentally by comparing capsular formation around implants in the presence and absence of AlloDerm in primates. Eight smooth-surfaced tissue expanders were implanted into eight African green monkeys. In four experimental animals, a sheet of AlloDerm was draped over the tissue expander so as to cover the implant. Four control animals underwent placement of a tissue expander only. Animals were killed after 10 weeks and specimens underwent histologic and immunohistochemical analysis. Hematoxylin and eosin staining of control specimens revealed the presence of a distinct layer of wavy, parallel arrays of collagen fibers consistent with capsule formation. Immunostaining identified abundant myofibroblasts, a profibrotic cell found in breast capsules. In the AlloDerm-covered specimens, no capsule layer was visible, and specimens stained weakly for myofibroblasts. The difference in myofibroblast staining intensity was statistically significant. The use of AlloDerm to partially enclose implants effectively prevented formation of a capsule in areas where AlloDerm contacted the implant at 10 weeks. Long-term studies will be required to determine whether this is a durable result that can be reproduced in humans.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Biomed Res Int
                Journal ID (iso-abbrev): Biomed Res Int
                Journal ID (publisher-id): BMRI
                Title: BioMed Research International
                Publisher: Hindawi Publishing Corporation
                ISSN (Print): 2314-6133
                ISSN (Electronic): 2314-6141
                Publication date (Print): 2014
                Publication date (Electronic): 3 September 2014
                Volume: 2014
                Electronic Location Identifier: 618206
                Affiliations
                1Department of Dermatology, University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy
                2Italian Society of Laser Dermatology (SILD), Via Nicolò dall'Arca 7, 70121 Bari, Italy
                3Department of Dermatology, University of Rome, Tor Vergata, Italy
                4Department of Dermatology, University of Bologna, Italy
                5Laboratory for Investigative Dermatology, The Rockefeller University, New York City, USA
                Author notes

                Academic Editor: Silvia Moretti

                Article
                DOI: 10.1155/2014/618206
                PMC ID: 4167959
                PubMed ID: 25276803
                SO-VID: dd4ee454-0420-453f-b08e-fef97faa98cc
                Copyright © Copyright © 2014 D. Piccolo et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 6 February 2014
                Date revision received : 15 June 2014
                Date accepted : 16 June 2014
                Categories
                Subject: Clinical Study

                Data availability:

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