Transplacental transmission of SARS-CoV-2 infection

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Abstract

SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients.

Abstract

Congenital infection of SARS-CoV-2 has been described, but the transmission routes remain unclear. Here, the authors report evidence of transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise.

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Most cited references 21

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Author and article information

Contributors

Daniele De Luca:

ORCID: http://orcid.org/0000-0002-3846-4834

dm.deluca@icloud.com

Journal

Journal ID (nlm-ta): Nat Commun

Journal ID (iso-abbrev): Nat Commun

Title: Nature Communications

Publisher: Nature Publishing Group UK (London )

ISSN (Electronic): 2041-1723

Publication date (Electronic): 14 July 2020

Publication date PMC-release: 14 July 2020

Publication date Collection: 2020

Volume: 11

Electronic Location Identifier: 3572

Affiliations

[1 ]Division of Obstetrics and Gynecology, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140 Clamart, France

[2 ]Division of Virology, Paul Brousse Hospital, Paris Saclay University Hospitals, APHP 12 Avenue Paul Vaillant Couturier, 94800 Villejuif, France

[3 ]ISNI 0000 0001 2175 4109, GRID grid.50550.35, Division of Pathology, Bicetre Hospital, , Paris Saclay University Hospitals, APHP, ; Le Kremlin-Bicêtre, France

[4 ]Division of Pediatrics and Neonatal Critical Care, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140 Clamart, France

[5 ]Division of Radiology, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140 Clamart, France

[6 ]Division of General Pediatrics, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140 Clamart, France

[7 ]Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris Saclay University, 63 Rue Gabriel Péri, 94270 Le Kremlin-Bicêtre, France

Author information

Alexandre J. Vivanti http://orcid.org/0000-0002-4921-0047

Jeremy Do Cao http://orcid.org/0000-0003-1333-2103

Alexandra Benachi http://orcid.org/0000-0001-6045-0765

Daniele De Luca http://orcid.org/0000-0002-3846-4834

Article

Publisher ID: 17436

DOI: 10.1038/s41467-020-17436-6

PMC ID: 7360599

PubMed ID: 32665677

SO-VID: dd6300e2-bea3-4226-9642-f65b01c36344

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.