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      Ischemia-reperfusion alters cardiac lipoprotein lipase.

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          Abstract

          Ischemia-reperfusion (I/R) is associated with changes in energy metabolism in the heart. However, the majority of studies have focused on examining rates and extent of fatty acid (FA) oxidation, with limited emphasis on FA delivery. We examined the influence of acute myocardial I/R on coronary lipoprotein lipase (LPL), the key enzyme responsible for triglyceride-lipoprotein hydrolysis and FA delivery to the heart. In a whole animal and an ex vivo model of I/R, we demonstrate increases in luminal LPL activity, an effect that involved signaling through nitric oxide. Given the damaging effect of excess FA utilization by the ischemic heart, strategies to restrict LPL at the vascular lumen would be an attractive therapeutic option in limiting I/R related cardiac injury.

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          Author and article information

          Affiliations
          [1 ] Cardiovascular Research Center, Department of Pediatrics, 430, Heritage Medical Research Centre, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G2S2, Canada.
          Journal
          Biochim. Biophys. Acta
          Biochimica et biophysica acta
          Elsevier BV
          0006-3002
          0006-3002
          Feb 2010
          : 1801
          : 2
          S1388-1981(09)00246-7
          10.1016/j.bbalip.2009.10.008
          19857601

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