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      Machado-Joseph disease enhances genetic fitness: a comparison between affected and unaffected women and between MJD and the general population.

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      Annals of human genetics

      Wiley

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          Abstract

          Machado-Joseph disease (MJD SCA3), a spinocerebellar ataxia related to expansion of a CAG tract, has already been related to anticipation and meiotic drift. However, fitness of MJD carriers has been little studied.

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          Author and article information

          Journal
          Ann. Hum. Genet.
          Annals of human genetics
          Wiley
          0003-4800
          0003-4800
          Jan 2008
          : 72
          : Pt 1
          Affiliations
          [1 ] Department of Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Brazil.
          Article
          AHG388
          10.1111/j.1469-1809.2007.00388.x
          17683516

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