For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
12
views
46
references
 Top references
cited by
11
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      361
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Enhanced Differentiation of Human Preosteoblasts on Electrospun Blend Fiber Mats of Polydioxanone and Anionic Sulfated Polysaccharides

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The viability and differentiation of SaOS-2 preosteoblasts on fiber mats of blends comprising of the biodegradable poly(ester-ether) polydioxanone (PDX) and the sulfate-containing anionic polysaccharides kappa-carrageenan (KCG) and fucoidan (FUC) were investigated for a range of different blend compositions. The detailed analysis of the blend nanofiber properties revealed a different degree of miscibility of PDX and the polysaccharide leading to a different enrichment at the surface of the blend nanofibers, which were observed to be stable in phosphate buffer solution (PBS) for up to 5 weeks. The fibrous mats of PDX/FUC led to the highest osteogenic differentiation with very good cell viability. The electrospun blend fibers also supported human-induced pluripotent stem (iPS) cells and iPS cell-derived embryoid bodies with high cell viability, which underlines the potential of these novel blend fiber systems for optimized performance in bone tissue engineering applications.

          Related collections

          Most cited references46

          • Record: found
          • Abstract: found
          • Article: not found

          Electrospinning of polymeric nanofibers for tissue engineering applications: a review.

          Quynh Pham, Upma Sharma, Antonios Mikos (2006)
          Interest in electrospinning has recently escalated due to the ability to produce materials with nanoscale properties. Electrospun fibers have been investigated as promising tissue engineering scaffolds since they mimic the nanoscale properties of native extracellular matrix. In this review, we examine electrospinning by providing a brief description of the theory behind the process, examining the effect of changing the process parameters on fiber morphology, and discussing the potential applications and impacts of electrospinning on the field of tissue engineering.
          Article 0 comments Cited 444 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Electrospun nanofibrous structure: A novel scaffold for tissue engineering

            Wan-Ju Li, Frank Ko, Rocky S Tuan … (2002)
            The architecture of an engineered tissue substitute plays an important role in modulating tissue growth. A novel poly(D,L-lactide-co-glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue-engineering applications. Electrospinning is a process whereby ultra-fine fibers are formed in a high-voltage electrostatic field. The electrospun structure, composed of PLGA fibers ranging from 500 to 800 nm in diameter, features a morphologic similarity to the extracellular matrix (ECM) of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, and effective mechanical properties. Such a structure meets the essential design criteria of an ideal engineered scaffold. The favorable cell-matrix interaction within the cellular construct supports the active biocompatibility of the structure. The electrospun nanofibrous structure is capable of supporting cell attachment and proliferation. Cells seeded on this structure tend to maintain phenotypic shape and guided growth according to nanofiber orientation. This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth. Copyright 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 613-621, 2002
            Article 0 comments Cited 430 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

              Jan Henkel, Maria Woodruff, Devakara R Epari … (2013)
              The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental “origin” require osseous reconstruction to ensure structural and functional integrity. Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.
              Article 0 comments Cited 218 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): ACS Biomater Sci Eng
                Journal ID (iso-abbrev): ACS Biomater Sci Eng
                Journal ID (publisher-id): ab
                Journal ID (coden): abseba
                Title: ACS Biomaterials Science & Engineering
                Publisher: American Chemical Society
                ISSN (Electronic): 2373-9878
                Publication date (Electronic): 12 October 2017
                Publication date (Print): 11 December 2017
                Volume: 3
                Issue: 12
                Pages: 3447-3458
                Affiliations
                [† ]Physical Chemistry I, Department of Chemistry and Biology & Research Center of Micro and Nanochemistry and Engineering (Cμ), University of Siegen , Adolf-Reichwein-Strasse 2, 57076 Siegen, Germany
                [‡ ]Biomaterials, Drug Delivery and Nanotechnology Unit, Centre for Biomedical and Biomaterials Research, MSIRI Building, University of Mauritius , Réduit 80837, Mauritius
                [§ ]Macromolecular Chemistry, Department of Chemistry and Biology, University of Siegen , Adolf-Reichwein-Strasse 2, 57076 Siegen, Germany
                Author notes
                Article
                DOI: 10.1021/acsbiomaterials.7b00350
                PMC ID: 5739512
                SO-VID: dd762a94-61aa-4150-82db-40c0ce6e9264
                Copyright © Copyright © 2017 American Chemical Society
                License:

                This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

                History
                Date received : 03 June 2017
                Date accepted : 12 October 2017
                Categories
                Subject: Article
                Custom metadata
                document-id-old-9 ab7b00350
                document-id-new-14 ab-2017-00350y
                ccc-price

                Keywords: anionic polysaccharides,electrospun fibers,cell viability,osteogenic differentiation,ips cell-derived embryoid bodies
                Data availability:
                Keywords: anionic polysaccharides, electrospun fibers, cell viability, osteogenic differentiation, ips cell-derived embryoid bodies

                Comments

                Comment on this article

                scite_

                Similar content361

                See all similar

                Cited by11

                See all cited by

                Most referenced authors575

                See all reference authors