This paper discusses a recently proposed scenario of a climate-induced Collapse of the Eastern Mediterranean in the 11th century AD. It demonstrates that such a scenario cannot be maintained when confronted with proxy data from various regions. On the other hand, data on the interplay between environment and economy in the Komnenian period (1081-1185) and evidence for a change of climatic conditions in the period of the Angeloi (1185-1204) is presented, arguing that climatic parameters should be taken into consideration when comparing socio-economic dynamics in the Eastern Mediterranean with those in Western Europe. The necessity of further research on the regional as well as over-regional level for many aspects of the interaction between human society and environment in the medieval Eastern Mediterranean is highlighted.