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      Community-level determinants of obesity: harnessing the power of electronic health records for retrospective data analysis

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          Abstract

          Background

          Obesity and overweight are multifactorial diseases that affect two thirds of Americans, lead to numerous health conditions and deeply strain our healthcare system. With the increasing prevalence and dangers associated with higher body weight, there is great impetus to focus on public health strategies to prevent or curb the disease. Electronic health records (EHRs) are a powerful source for retrospective health data, but they lack important community-level information known to be associated with obesity. We explored linking EHR and community data to study factors associated with overweight and obesity in a systematic and rigorous way.

          Methods

          We augmented EHR-derived data on 62,701 patients with zip code-level socioeconomic and obesogenic data. Using a multinomial logistic regression model, we estimated odds ratios and 95% confidence intervals (OR, 95% CI) for community-level factors associated with overweight and obese body mass index (BMI), accounting for the clustering of patients within zip codes.

          Results

          33, 31 and 35 percent of individuals had BMIs corresponding to normal, overweight and obese, respectively. Models adjusted for age, race and gender showed more farmers’ markets/1,000 people (0.19, 0.10-0.36), more grocery stores/1,000 people (0.58, 0.36-0.93) and a 10% increase in percentage of college graduates (0.80, 0.77-0.84) were associated with lower odds of obesity. The same factors yielded odds ratios of smaller magnitudes for overweight. Our results also indicate that larger grocery stores may be inversely associated with obesity.

          Conclusions

          Integrating community data into the EHR maximizes the potential of secondary use of EHR data to study and impact obesity prevention and other significant public health issues.

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          Most cited references35

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          General cardiovascular risk profile for use in primary care: the Framingham Heart Study.

          Separate multivariable risk algorithms are commonly used to assess risk of specific atherosclerotic cardiovascular disease (CVD) events, ie, coronary heart disease, cerebrovascular disease, peripheral vascular disease, and heart failure. The present report presents a single multivariable risk function that predicts risk of developing all CVD and of its constituents. We used Cox proportional-hazards regression to evaluate the risk of developing a first CVD event in 8491 Framingham study participants (mean age, 49 years; 4522 women) who attended a routine examination between 30 and 74 years of age and were free of CVD. Sex-specific multivariable risk functions ("general CVD" algorithms) were derived that incorporated age, total and high-density lipoprotein cholesterol, systolic blood pressure, treatment for hypertension, smoking, and diabetes status. We assessed the performance of the general CVD algorithms for predicting individual CVD events (coronary heart disease, stroke, peripheral artery disease, or heart failure). Over 12 years of follow-up, 1174 participants (456 women) developed a first CVD event. All traditional risk factors evaluated predicted CVD risk (multivariable-adjusted P<0.0001). The general CVD algorithm demonstrated good discrimination (C statistic, 0.763 [men] and 0.793 [women]) and calibration. Simple adjustments to the general CVD risk algorithms allowed estimation of the risks of each CVD component. Two simple risk scores are presented, 1 based on all traditional risk factors and the other based on non-laboratory-based predictors. A sex-specific multivariable risk factor algorithm can be conveniently used to assess general CVD risk and risk of individual CVD events (coronary, cerebrovascular, and peripheral arterial disease and heart failure). The estimated absolute CVD event rates can be used to quantify risk and to guide preventive care.
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            Systematic review: impact of health information technology on quality, efficiency, and costs of medical care.

            Experts consider health information technology key to improving efficiency and quality of health care. To systematically review evidence on the effect of health information technology on quality, efficiency, and costs of health care. The authors systematically searched the English-language literature indexed in MEDLINE (1995 to January 2004), the Cochrane Central Register of Controlled Trials, the Cochrane Database of Abstracts of Reviews of Effects, and the Periodical Abstracts Database. We also added studies identified by experts up to April 2005. Descriptive and comparative studies and systematic reviews of health information technology. Two reviewers independently extracted information on system capabilities, design, effects on quality, system acquisition, implementation context, and costs. 257 studies met the inclusion criteria. Most studies addressed decision support systems or electronic health records. Approximately 25% of the studies were from 4 academic institutions that implemented internally developed systems; only 9 studies evaluated multifunctional, commercially developed systems. Three major benefits on quality were demonstrated: increased adherence to guideline-based care, enhanced surveillance and monitoring, and decreased medication errors. The primary domain of improvement was preventive health. The major efficiency benefit shown was decreased utilization of care. Data on another efficiency measure, time utilization, were mixed. Empirical cost data were limited. Available quantitative research was limited and was done by a small number of institutions. Systems were heterogeneous and sometimes incompletely described. Available financial and contextual data were limited. Four benchmark institutions have demonstrated the efficacy of health information technologies in improving quality and efficiency. Whether and how other institutions can achieve similar benefits, and at what costs, are unclear.
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              State of disparities in cardiovascular health in the United States.

              Reducing health disparities remains a major public health challenge in the United States. Having timely access to current data on disparities is important for policy and program development. Accordingly, we assessed the current magnitude of disparities in cardiovascular disease (CVD) and its risk factors in the United States. Using national surveys, we determined CVD and risk factor prevalence and indexes of morbidity, mortality, and overall quality of life in adults > or =18 years of age by race/ethnicity, sex, education level, socioeconomic status, and geographic location. Disparities were common in all risk factors examined. In men, the highest prevalence of obesity (29.2%) was found in Mexican Americans who had completed a high school education. Black women with or without a high school education had a high prevalence of obesity (47.3%). Hypertension prevalence was high among blacks (39.8%) regardless of sex or educational status. Hypercholesterolemia was high among white and Mexican American men and white women in both groups of educational status. Ischemic heart disease and stroke were inversely related to education, income, and poverty status. Hospitalization was greater in men for total heart disease and acute myocardial infarction but greater in women for congestive heart failure and stroke. Among Medicare enrollees, congestive heart failure hospitalization was higher in blacks, Hispanics, and American Indians/Alaska Natives than among whites, and stroke hospitalization was highest in blacks. Hospitalizations for congestive heart failure and stroke were highest in the southeastern United States. Life expectancy remains higher in women than men and higher in whites than blacks by approximately 5 years. CVD mortality at all ages tended to be highest in blacks. Disparities in CVD and related risk factors remain pervasive. The data presented here can be invaluable for policy development and in the planning, implementation, and evaluation of interventions designed to eliminate health disparities.
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                Author and article information

                Contributors
                Journal
                BMC Med Inform Decis Mak
                BMC Med Inform Decis Mak
                BMC Medical Informatics and Decision Making
                BioMed Central
                1472-6947
                2014
                8 May 2014
                : 14
                : 36
                Affiliations
                [1 ]Department of Biomedical Informatics, College of Medicine, 250 Lincoln Tower 1800 Cannon Drive, 43210 Columbus, OH, USA
                [2 ]Division of Epidemiology, College of Public Health; The Ohio State University, Columbus, OH, USA
                Article
                1472-6947-14-36
                10.1186/1472-6947-14-36
                4024096
                24886134
                dd9f9f13-fd53-4ad8-b444-d9bb226e9bc8
                Copyright © 2014 Roth et al.; licensee BioMed Central Ltd.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 9 February 2014
                : 30 April 2014
                Categories
                Research Article

                Bioinformatics & Computational biology
                electronic health record,obesity,data integration,community data,clinical research informatics,prevention,access,social determinants of health

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