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Lowbury Lecture 2018. Chlorhexidine-Based Decolonization to Reduce Healthcare-Associated Infections and Multidrug-Resistant Organisms (MDROs): Who, What, Where, When, and Why?
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Abstract
Body surface decolonization with chlorhexidine bathing and nasal mupirocin has become
a simple solution for prevention of healthcare-associated infections. The clinical
trial evidence for this practice will be reviewed to understand who benefits from
this practice, for what reasons, and at what times. The method of bathing and nasal
decolonization will also be discussed as proper application is needed for maximal
effectiveness. Finally, the conflict between current effectiveness and future potential
for fueling resistance is considered.