This study presents exact bending solution of fully clamped orthotropic rectangular plates subjected to arbitrary loads resting on elastic foundations, based on the finite integral transform method. In this method, it is not necessary to determine the deformation function because the basic governing equations of the classical plate theory for orthotropic plates have been used. A detailed parametric study is conducted to elucidate the influences of stiffness of elastic medium, plate length, flexural rigidities and distributed transverse load on the deflections. The applicability of the method is extensive since it can solve any plates with different loadings. Numerical results are presented to demonstrate the validity and accuracy of the approach, as it is totally in agreement with the other studies.