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      Corneal Penetration and Ocular Bioavailability of Drugs

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      Journal of Ocular Pharmacology and Therapeutics
      Mary Ann Liebert Inc

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          The metabolic basis to the fluid pump in the cornea.

          1. A technique for isolating and perfusing the rabbit cornea is described, which allowed its thickness to be continuously measured under the microscope. The reversal of thickness of the cold-swollen cornea on perfusion with various solutions at 37 degrees C was studied.2. It was found that only a combination of adenosine and glutathione was able to reliably reverse the thickness to its normal value. This mechanism is sodium, bicarbonate, and oxygen dependent. Inhibitors of glycolysis or electron transport stop the reversal process.3. The findings are consistent with a need for an ATPase but are not capable of distinguishing among several possibilities for its regulation.
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            Selection of a Reference Partitioning System for Drug Design Work

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              Effect of particle size on ophthalmic bioavailability of dexamethasone suspensions in rabbits.

              Three suspensions of 0.1% [3H]dexamethasone were prepared with mean particle sizes of 5.75, 11.5, and 22.0 micron. The suspensions were dosed topically to the right eyes of rabbits. Their bioavailability was compared by measuring aqueous humor and corneal levels over 5 hr. A statistically significant rank-order correlation was observed between increasing drug levels and decreasing particle size.
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                Author and article information

                Journal
                Journal of Ocular Pharmacology and Therapeutics
                Journal of Ocular Pharmacology and Therapeutics
                Mary Ann Liebert Inc
                1080-7683
                1557-7732
                January 1985
                January 1985
                : 1
                : 3
                : 309-326
                Article
                10.1089/jop.1985.1.309
                ddd0a13a-908a-4005-9909-6913bac660d1
                © 1985

                http://www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/

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