17
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      How I treat hemophagocytic lymphohistiocytosis in the adult patient.

      1 , 2
      Blood

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Hemophagocytic lymphohistiocytosis (HLH) is a devastating disorder of uncontrolled immune activation characterized by clinical and laboratory evidence of extreme inflammation. This syndrome can be caused by genetic mutations affecting cytotoxic function (familial HLH) or be secondary to infectious, rheumatologic, malignant, or metabolic conditions (acquired HLH). Prompt recognition is paramount and, without early treatment, this disorder is frequently fatal. Although HLH is well described in the pediatric population, less is known about the appropriate work-up and treatment in adults. Here, we review the clinical characteristics, diagnosis, and treatment of HLH in adults.

          Related collections

          Author and article information

          Journal
          Blood
          Blood
          1528-0020
          0006-4971
          May 7 2015
          : 125
          : 19
          Affiliations
          [1 ] Department of Medicine and.
          [2 ] Department of Medicine and Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
          Article
          blood-2015-01-551622
          10.1182/blood-2015-01-551622
          25758828
          ddd3e146-8551-46db-98ac-1098e91ba4fd
          © 2015 by The American Society of Hematology.
          History

          Comments

          Comment on this article