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Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.
Gemma G Kenter
1 ,
Marij J P Welters ,
A Rob P M Valentijn ,
Margriet J G Lowik ,
Dorien M A Berends-van der Meer ,
Annelies P G Vloon ,
Farah Essahsah ,
Lorraine M Fathers ,
Rienk Offringa ,
Jan Wouter Drijfhout ,
Amon R Wafelman ,
Jaap Oostendorp ,
Gert Jan Fleuren ,
Sjoerd H van der Burg ,
Cornelis J M Melief
Nov 05 2009
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Abstract
Vulvar intraepithelial neoplasia is a chronic disorder caused by high-risk types of human papillomavirus (HPV), most commonly HPV type 16 (HPV-16). Spontaneous regression occurs in less than 1.5% of patients, and the rate of recurrence after treatment is high.